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IRCT20180116038391N1 IRCT 2018-03-03 Iran University of Medical Sciences Evaluation of the effectiveness of oral Aspirin in reducing complex regional pain syndrome (CRPS) Evaluation of the effectiveness of oral Aspirin in reducing complex regional pain syndrome (CRPS) in distal radius fractures treated with closed reduction and percutaneous pinning 2016-04-20 anticipated 80 Complete https://irct.ir/trial/29078 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: individual randomization with closed envelope, Blinding description: The patients were randomly allocated a box containing aspirin or placebo (randomization was performed according to a table of random numbers by the pharmacist). All boxes and capsules had been made by a pharmacist in the same appearance and taste. The study was double-blind. All participants, nurses, physiotherapists, physicians and researchers were unaware of the treatment allocation and the pharmacist was the only individual with the access to the code until the end of the analysis. 3 Condition 1: Complex regional pain syndrome. Condition 2: distal radius fracture. Intervention 1: Intervention group: Aspirin 500mg po daily for 7days. Intervention 2: Control group: placebo capsule daily for 7 daye. Yes - There is a plan to make this available What will be shared: Information about fractures,medical treatment and the incidence of CRPS When: After publishing the results in journals To whom: Physicians, physiotherapists Conditions: Only for scientific purposes Where to obtain: Email How to obtain: Email Comments:
public Nima Hosseinzadeh
Rasool Akram Hospital, Niayesh Street, Sattarkhan Street
Tehran Iran (Islamic Republic of) +98 21 6435 2264 hosseinzade.nima@gmail.com Iran University of Medical Sciences scientific Nima Hosseinzadeh
Rasool Akram Hospital, Niayesh Street, Sattarkhan Street
Tehran Iran (Islamic Republic of) +98 21 6435 2264 hosseinzade.nima@gmail.com Iran University of Medical Sciences Iran (Islamic Republic of) closed, unilateral, extra-articular distal radius fracture eighteen years and over 18 years no limit Both history of taking medications that were involved in the treatment of CRPS (such as antidepressants, anticonvulsants, corticosteroids and vitamin C) previous wrist or hand fracture on the same side neurovascular injury fractures with high energy mechanism or multiple trauma-injured patients, multiple fractures at different places contraindication to take aspirin and acetaminophen open fractures articular displacement requiring open reduction G90.5 S62 Complex regional pain syndrome I (CRPS I) Fracture at wrist and hand level Prevention Prevention Intervention group: Aspirin 500mg po daily for 7days Control group: placebo capsule daily for 7 daye Complex regional pain syndrome. Timepoint: 2, 4, 6 and 12 week post operation. Method of measurement: Budapest’s criteria. Iran University of Medical Sciences Approved 2017-06-19 Ethics Committee Iran University of Medical Sciences Hazrat-e Rasool Hospital, Niyayesh Street, Sattarkhan Street Tehran Tehran Iran (Islamic Republic of)