IRCT20180103038196N2 IRCT 2018-06-07 Gorgan University of Medical Sciences Efficacy of Adding Folic Acid to Sodium Valproate on patients with Acute Mania Compare Effectiveness of Adding Folic Acid to Sodium Valproate in Treating patients with Acute Mania 2018-02-20 anticipated 60 Complete https://irct.ir/trial/29283 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: A sample of 60 patients was selected based on the inclusion criteria and randomly divided into two groups of intervention and control (each group was 30 patients). Patients will be matched for age and sex, Blinding description: Therapists and prescribing nurses and also data analyzer did not know the type of medication prescribed for patients. Therefore the study was double blind. 3 Acute Mania. Intervention 1: Intervention group: patients receiving folic acid + sodium valproate .Sodium valproate starts at 400 mg per day and will increase up to maximum of 20 mg per kg per day or the highest dose that the patient can withstand. In addition sodium valproate, the group will receive one tablet of folic acid 5 milligrams a day. Intervention 2: Control group: patients receiving placebo + sodium valproate . Sodium valproate starts at 400 mg per day and will increase up to a maximum of 20 mg per kg per day or the highest dose that the patient can withstand.In addition to sodium valproate, the control group will receive one placebo tablet. Yes - There is a plan to make this available What will be shared: All data is shareable When: from 2018 To whom: Professors and people studying at medical universities Conditions: All data is shareable Where to obtain: salimia92@gmail.com How to obtain: not have Comments: