IRCT20121204011662N12 IRCT 2018-02-27 Shiraz University of Medical Sciences Comparison the effect of magnesium sulfate with pregabalin on prevention of the pain severity induced by remifentanil. Comparison the effect of magnesium sulfate with pregabalin on prevention of remifentanil – induced hyperalgesia in patients undergoing rhinoplasty. A randomized clinical trial 2018-02-20 anticipated 105 Complete https://irct.ir/trial/29324 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: All eligible patients will be randomized according to simple randomization table into three equal groups A, B, C, Blinding description: For blindness, All of the drugs solution( Magnesium Sulfate and normal saline) of this study will be prepared in 50 ml syringes that are equal in shape and placebo of the pregabalin in the pregabalin like capsule, by only person who aware of study's groups. Anesthesiologist, patients and all persons who will collaborated in this study, will not aware of patients groups. N/A Postoperative pain management following rhinoplasty.. Intervention 1: Intervention group: Patients in group A will receive 300 mg pregabalin one hour before entering operation room. Intervention 2: Intervention group: Patients in group B will receive 30 mg magnesium sulfate at induction of anesthesia and then infusion 10 mg/kg/hr during anesthesia. Intervention 3: Control group: Patients in group C will receive 10 ml saline solution at induction of anesthesia then 1ml/Kg/hr normal saline solution during anesthesia. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information