IRCT20140519017756N38 IRCT 2018-02-19 Birjand University of Medical Sciences Effect of grape seed extract 5% ointment on appendectomy wound healing Clinical trial comparing topical effects of grape seed 5% extract ointment, placebo, and no intervention on appendectomy wound healing 2018-01-21 anticipated 78 Complete https://irct.ir/trial/29351 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: The participants will be selected based on the inclusion criteria via purposive sampling method. Nonetheless, they will be assigned into study groups randomly via permutation blocking randomization. There are three cards, a, b and c, indicative of the study groups. Each participants will select one and will be allocated into the associated group. 1 appendectomy wound healing. Intervention 1: Intervention group 1 (grape seed ointment): Grape seed 5% extract ointment will be applied in 1 centimeter width and one millimeter thickness onto the sutured region using sterilized, graded paper. This is performed twice a day (12 ± 2 hours) from the second to the sixteenth post-operative day. Intervention 2: Control group (placebo): Vaseline ointment will be applied in 1 centimeter width and one millimeter thickness onto the sutured region using sterilized, graded paper. This is performed twice a day (12 ± 2 hours) from the second to the sixteenth post-operative day. Intervention 3: Control group (No intervention): In the control group, no ointment is used. No - There is not a plan to make this available Justification or reason for not sharing IPD is Upon the participants' request, no information can be shared.