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IRCT20151228025732N30 IRCT 2018-02-18 Semnan University of Medical Sciences The effect of dydrogesterone in prevention of preeclampsia in high-risk pregnancy of primigravidae women that has been referred to gynecology clinic The effect of dydrogesterone in prevention of preeclampsia in high-risk pregnancy of primigravidae women that has been referred to gynecology clinic 2017-12-12 anticipated 168 Complete https://irct.ir/trial/29364 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Block randomization; Individual; Random Number Tables. Randomized permutation blocks (block 2). Using Excel software to generate random number tables, Blinding description: To a group of A drug packs and to the second group of B drug packs will be given; thus, the patients and the investigator (the presenter) will be unaware of the treatment group and placebo. N/A Pregnancy, childbirth and the puerperium. Intervention 1: Control group: placebo from the 7th week of pregnancy (it consists of sugar and starch, in terms of shape, size and color, exactly the same as Duphaston®, 3 times a day) until 14-16 weeks of pregnancy. Intervention 2: Intervention group: Daily 30 mg dydrogesterone from the 7th week of pregnancy (10 mg Duphaston® tablet manufactured by ABBOTT Heal THCARE, Netherlands, (Importer of Behestan Pharmaceutical Company), 3 times a day) until 14-16th week of pregnancy. Yes - There is a plan to make this available What will be shared: - When: - To whom: Only available to scholars working in academic institutions. Conditions: In case of relevant studies. Where to obtain: Sanam Moradan. Amir Al-Momenin Hospital, Mostafa Khomeini Blvd, Semnan. 00989127312407 How to obtain: - Comments:
public Sanam Moradan
Amir Al-Momenin Hospital, Mostafa Khomeini Blvd
Semnan Iran (Islamic Republic of) 3514799442 +98 23 3345 1336 are20935@gmail.com Semnan University of Medical Sciences scientific Sanam Moradan
Amir Al-Momenin Hospital, Mostafa Khomeini Blvd
Semnan Iran (Islamic Republic of) 3514799442 +98 23 3345 1336 are20935@gmail.com Semnan University of Medical Sciences Iran (Islamic Republic of) Women that have aged 18 to 40 years Nulliparous Women The body mass index is equal to or greater than 30 kg / m2 18 years 40 years Female The history of consumption of progesterone supplements in the last 6 months Contraindications for the use of progesterone Use of drugs that induce liver enzymes activation (carbamazepine, phenytoin and rifampin) Diagnosis of embryonic anomalies by ultrasound Previous cases of systemic diseases, such as asthma, diabetes, liver and kidney disorders, cardiovascular disease, connective tissue diseases. O00-O99 Pregnancy, childbirth and the puerperium Diagnosis Treatment - Drugs Control group: placebo from the 7th week of pregnancy (it consists of sugar and starch, in terms of shape, size and color, exactly the same as Duphaston®, 3 times a day) until 14-16 weeks of pregnancy. Intervention group: Daily 30 mg dydrogesterone from the 7th week of pregnancy (10 mg Duphaston® tablet manufactured by ABBOTT Heal THCARE, Netherlands, (Importer of Behestan Pharmaceutical Company), 3 times a day) until 14-16th week of pregnancy. Vaginal bleeding. Timepoint: During pregnancy and after childbirth. Method of measurement: Examination. Semnan University of Medical Sciences Approved 2018-02-06 Ethics committee of Semnan University of Medical Sciences Semnan University of Medical Sciences, Basij Blvd, Semnan Semnan Semnan Iran (Islamic Republic of)