IRCT20140519017756N39 IRCT 2018-02-20 Birjand University of Medical Sciences Effects of levetiracetam, sodium valproate, and nortriptyline on migraine headaches Comparison of the effects of levetiracetam, sodium valproate, and nortriptyline on migraine headaches control in migraine patients 2018-01-30 anticipated 120 Complete https://irct.ir/trial/29496 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: The participants will be allocated into study groups via permuted block randomization. 3 Migraine headaches. Intervention 1: Intervention Group 1 (Levetiracetam): These patients will receive levetiracetam which will start at a dose of 250 milligrams per day in the first week followed by an increased dose of 250 milligrams per week reaching a dose of 1000 milligrams per day in the fourth week. Intervention 2: Intervention Group 2 (Sodium Valproate): These patients will receive 500 milligrams of sodium valproate per day, starting at 250 mg per day in the first week. In the second week until the end of the fourth week of intervention, patients will receive 500 milligrams per day (250 milligrams twice a day). Intervention 3: Intervention Group 3 (Nortriptyline): These patients will be prescribed nortriptyline at a dose of 25 milligrams per day throughout the study. No - There is not a plan to make this available Justification or reason for not sharing IPD is As part of the conditions set by participants for participation, no data about them can be distributed.