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IRCT20180210038681N1 IRCT 2018-05-01 Khoram-Abad University of Medical Sciences The effect of dexamethasone and endonestrone premedication on the incidence of nausea and vomiting after cesarean section A comparative study of the effects of Dexamethasone and Ondansetron on nausea and vomiting in cesarean section under spinal anesthesia by Bupivacaine (Marcaine) 2018-01-29 anticipated 120 Complete https://irct.ir/trial/29582 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: The samples were selected purposefully and were assigned to the study groups using the stratified randomized blocks. nullipara/multi para pregnancy is considered as strata in this study, Blinding description: The Anesthesiologist was not aware of the type of drug used to prevent nausea and vomiting. The information was provided as a checklist and given to the inquirer who was not informed about the type of drugs for the patients. The incidence of nausea and vomiting in the patient was recorded 0 , 2 and 6 hours later in the PACU. 3 nausea and vomiting. Intervention 1: Intervention group (1) used single bolus dose of Dexamethasone (8 mg ) simultaneously with prep and drep, after spinal anesthesia with bupivacaine (0.5% ) and spinal needle 25 gauge. Intervention 2: Intervention group (2) used single bolus dose of ondansetrone (4 mg ) simultaneously with prep and drep, after spinal anesthesia with bupivacaine (0.5% ) and spinal needle 25 gauge. Yes - There is a plan to make this available What will be shared: The patients are divided into two groups A and B, and personal information of the patients remains confidential with the researcher. When: After completing the study, the information is presented in an article and immediately available to the public. To whom: The results are publicly available after printing and publication. Conditions: An analysis of the data delivered is authorized by the written permission of the persons in the article. Where to obtain: After publication of the article, people can submit articles by visiting Khorramabad University of Medical Sciences or through their respective websites. How to obtain: Immediately after referring to the Khorramabad University of Medical Sciences or the relevant websites, the article is available to the referring. Comments:
public Jahanbahsh rezanejadei
Paramedicine and Nutriton Campus, Next to the social security hospital, eastern Goldasht
Khorramabad Iran (Islamic Republic of) 6819789741 +98 66 3342 0030 rezanezhdi.j@lums.ac.ir Khoram-Abad University of Medical Sciences scientific Jahanbakhsh Razanejadi
Paramedicine and Nutriton Campus, Next to the social security hospital, eastern Goldasht
khorramabad Iran (Islamic Republic of) 6819789741 +98 66 3340 6099 rezanezhadi.j@lums.ac.ir Khoram-Abad University of Medical Sciences Iran (Islamic Republic of) All patients who have attended for elective cesarean section In the ASA class one and two being in fertility age Patients with normal, mild or moderate stress, anxiety and depression level Patients who will undergo spinal anesthesia with bupivacaine 0.5% 15 years 45 years Female Patients suffering from pregnancy toxicity ( eclampsia- preclampsia) or history of motion sickness, history of meniere disease, and migraine BMI greater than 40 history of PONV( post opreative neusea and vomiting ) severe or very severe level Stress , anxiety and depression Cigarette smoking and opoid drug consumption Patients that donot to cooperate Patients who undergo spinal anesthesia with lidocaine 5% Patients who receive atropine during opreation Treatment - Drugs Treatment - Drugs Intervention group (1) used single bolus dose of Dexamethasone (8 mg ) simultaneously with prep and drep, after spinal anesthesia with bupivacaine (0.5% ) and spinal needle 25 gauge. Intervention group (2) used single bolus dose of ondansetrone (4 mg ) simultaneously with prep and drep, after spinal anesthesia with bupivacaine (0.5% ) and spinal needle 25 gauge. Nausea. Timepoint: In PACU (at 0 oclock) and 2 oclock and after 6 oclock, the incidence of nausea and vomiting in the patient. Method of measurement: VAS ( Visual analog scale ). Vomiting. Timepoint: At PACU (at the begining) and 2 hours and 6 hours later. Method of measurement: Interview with patient. Stress, depression and anxiety. Timepoint: In the recovery before surgery. Method of measurement: Depression‚ Anxiety‚ Stress Scale (DASS). Khoram-Abad University of Medical Sciences Approved 2017-07-31 Ethics Committee of Lorestan University of Medical Sciences Haj Karim Asali charity Hospital, at the begining of Felestin alley, Doctor Shariati Avenue Khorramabad Lorestan Iran (Islamic Republic of)