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IRCT20161207031288N3 IRCT 2018-03-04 Center of research and training in skin diseases and leprosy Effect of topical solution of Cetirizine on Androgenetic Alopecia Preparation and evaluation of topical solution of Cetirizine in prevention and treatment of Androgenetic Alopecia 2018-01-20 anticipated 40 Complete https://irct.ir/trial/29721 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: By using the random numbers table, Blinding description: In this study patients are blind to the type of intervention they receive. Patients in both treatment groups will use topical formulation with similar physical appearance and packaging. 3 Androgenetic alopecia. Intervention 1: Intervention group: using Cetirizine topical solution, twice a day in hair- loss areas for 4 months. Intervention 2: Control group: using minoxidil topical solution, twice a day in hair- loss areas for 4 months. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is not decided yet
public Delaram Hossein Mostafa
no. 5; 46 alley; Asad abadi ave; Tehran
Tehran Iran (Islamic Republic of) 1436764963 +98 21 8805 9151 delaram_m72@yahoo.com Islamic Azad University scientific Delaram Hossein Mostafa
no.5 ; 46 alley; asad abadi ave; Tehran
Tehran Iran (Islamic Republic of) 1436764963 +98 21 8805 9151 delaram_m72@yahoo.com Islamic Azad University Iran (Islamic Republic of) Males st the age of 18 to 49 years Male pattern hair-loss should be at 2,3,4 in Norwood Scale Signed informed consent voluntarily and knowingly 18 years 49 years Male History of allergy to Cetirizine or Minoxidil Using 5-alpha reductase inhibitor in the last year Using Isotretinion over the past year Using nutritional supplement and herbal remedies for hair growth in the last 3 months Chemotherapy in the last year Scalp has been exposed to radiation in the past year History of uncontrolled Blood Pressure History of Hypotention Taking systemic Steroid for more than 14 days in the last 2 months L64 Androgenic alopecia Treatment - Drugs Treatment - Drugs Intervention group: using Cetirizine topical solution, twice a day in hair- loss areas for 4 months. Control group: using minoxidil topical solution, twice a day in hair- loss areas for 4 months. Hair count. Timepoint: Before intervention , two months later, 4 months later. Method of measurement: fotofinder trichoscale. Hair density. Timepoint: Before intervention , two months later, 4 months later. Method of measurement: fotofinder trichoscale. Anagen -telogen hair percantage. Timepoint: Before intervention , two months later, 4 months later. Method of measurement: fotofinder trichoscale. Number and density of vellus hair to terminal hair. Timepoint: Before intervention , two months later, 4 months later. Method of measurement: fotofinder trichoscale. Center of research and training in skin diseases and leprosy Approved 2017-10-29 Ethics committee of Pharmaceutical Sciences branch , Islamic Azad University Pharmaceutical sciences branch , Islamic Azad University, Yakhchal street , Shariati street , Tehran tehran Tehran Iran (Islamic Republic of)