IRCT20180219038792N1 IRCT 2019-01-02 Iranian academic center for education culture and research Comparison of double stimulation protocol with high dose of gonadotropin protocol in patients with poor ovarian response Comparison of double stimulation protocol to the approach using antagonist with high dose of gonadotropin in patients with poor ovarian response in avicenna infertility center 2018-04-04 anticipated 60 Complete https://irct.ir/trial/29805 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: A random specific code was allocated for each of 500 poor responders. A sample size of 60 was calculated based on the relating formula. 60 patients with poor response were randomly selected and divided into two groups of 30. Group A was selected for intervention and group B was considered as control. N/A Poor ovarian responds patients. Intervention 1: This study is a prospective randomized clinical trial. Patients who are nominated for ICSI because of POR are divided into two groups of 30 individuals randomly. After completing the consent, they will be placed in Double Stimulation group or a high dose antagonist gonadotrophin. First group, the starting day of the menstrual period begins with letrozole and clomiphene, and from the fourth day starts 150 units of gonadotrophin. Intervention 2: Control group: second group from the second day of the menstrual cycle, gonadotrophin starts at a dose of 450-400 units, and the dose is adjusted depending on the response of the ovaries. Both groups were evaluated for the number and quality of oocytes and embryos obtained, pregnancy status and serum levels of FSH, LH, Estradiol, Progesterone. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information