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IRCT20180127038515N1 IRCT 2018-03-19 Mashhad University of Medical Sciences Effect of Colchicine in improvement of myocardial infarction patients undergoing therapeutic intervention Evaluation of effects of Colchicine on corrected Thrombolysis In Myocardial Infarction (TIMI) frame in ST segment elevation myocardial infarction patients undergoing primary percutaneous coronary intervention (PPCI) 2017-04-21 anticipated 60 Complete https://irct.ir/trial/29855 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: simple randomization, Blinding description: participants and researcher will be blinded by coded-pockets toward administrating drugs. 2 ST segment elevation myocardial infarction. Intervention 1: Intervention group: administration of 2mg Colchicine. Intervention 2: Control group: administration of 2mg placebo tablet. Yes - There is a plan to make this available What will be shared: Article in journals and report in conferences and seminar When: unlimited To whom: general academic or non-academic researcher Conditions: By getting permission from main researcher of this project Where to obtain: main researcher of project How to obtain: sending request to main researcher of the project and after validation the data will be send to requester Comments:
public Samaneh Hassanzadeh Avval
Shariati Sqaure
Mashhad Iran (Islamic Republic of) 9176999311 +98 51 3854 3031 s.hassanzadeh1@gmail.com Mashhad University of Medical Sciences scientific Ramin Khameneh Bagheri
Cardiovascular department, First floor, Qaem Hospital, Shariati Square
Mashhad Iran (Islamic Republic of) 9919991766 +98 51 3840 0000 khamenehbr@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) stability for at least previous 6 months ability for participation in followups consent for enter in the study 18 years 85 years Both contraindication of Colchicine consumption infectious disorder or active inflammatory disorder or known malignancy current treatment by Corticosteroid or other anti-inflammatory drugs known sensitivity to Colchicine or current treatment by Colchicine severe renal failure (GFR<30) liver failure cardiac arrest ventricular fibrillation or symptomatic cardiogenic shock stent thrombosis occurrence of angina 48 hours before infarction previous myocardial infarction left main coronary artery or left circumflex occlusion existence of metal implant pregnancy I21 ST elevation (STEMI) and non-ST elevation (NSTEMI) myocardial infarction Treatment - Drugs Treatment - Drugs Intervention group: administration of 2mg Colchicine Control group: administration of 2mg placebo tablet Corrected TIMI frame count index. Timepoint: before starting PCI, after doing PCI. Method of measurement: By using angiography device. Mashhad University of Medical Sciences Approved 2017-01-04 Ethics committee of Mashhad University of Medical Sciences Daneshgah Street Mashhad Razavi Khorasan Iran (Islamic Republic of)