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IRCT20121216011763N34 IRCT 2018-08-18 Esfahan University of Medical Sciences Effect of Curcumin on Migraine The Effect of Curcumin on Symptoms and Severity of Headache and pro Inflammatory Markers ,Symptoms of Depression ,Anxiety and Stress in Women with Migraine 2017-12-30 anticipated 44 Complete https://irct.ir/trial/29997 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: In this study, simple randomization method was used, randomization unit was used individually and we used statistical software. We assigned each participant to study a code and entered the code into SPSS software. The software selected a random number, Blinding description: In order to eliminate the error from the patient's and researcher's awareness of the type of treatment received and its possible effect on the outcome of the study, we will conduct a double-blind study. Due to the fact that placebo and supplementation of curcumin are completely in the capsule, the participants and the researcher are not aware of the type of supplement they received. N/A Migraine. Intervention 1: Intervention group: Two oral supplementation curcumin 500 mg are given for 8 weeks. Intervention 2: Control group: Two placebo (corn starch) 500 mg for 8 weeks. Yes - There is a plan to make this available What will be shared: A lot of information will be available to people. When: After printing the article To whom: researchers Conditions: To do similar designs Where to obtain: Answer the person How to obtain: By email, they can access the information. Comments:
public Sheyda Rezaei
اصفهان-چهارباغ 14/5000 Isfahan-Chaharbagh
Isfahan Iran (Islamic Republic of) 8135798111 +98 31 3626 9719 sheyda_rezaei@yahoo.com Esfahan University of Medical Sciences scientific Reza Amani
Isfahan-1000 Jerebar-Faculty of Nutrition
Isfahan Iran (Islamic Republic of) 8135798111 +98 31 3792 3171 rezaamani@hotmail.com Esfahan University of Medical Sciences Iran (Islamic Republic of) Aged 20-50 years Diagnose of migraine by neurologist willing to participate on study Lack of severe depression and anxiety and stress Not taking Vitamin and Antioxidant supplements (Vitamin E and C ، Selenium ، Zinc and Beta carotene) Not having tension headaches Not taking Anti migraine drugs The absence of severe chronic disease such as Cancer ، Hepatitis ، pancreatitis ، diabetes ، Thyroid disorders ، Kidney and Liver disease Having no inflammatory diseases or history of heart disease and stroke and taking anti-inflammatory drugs 20 years 50 years Female Unwilling to participate in the study Use of antioxidant supplements, vitamins and anti-migraine drugs Chronic diseases and tension headaches Indication of allergic symptoms due to curcumin supplementation Pregnancy and lactation, or any major change in lifestyle or diet G43 G43 Other Other Intervention group: Two oral supplementation curcumin 500 mg are given for 8 weeks. Control group: Two placebo (corn starch) 500 mg for 8 weeks. Severity of migraine, migraine frequency and duration of headache. Timepoint: The beginning and the end of the study. Method of measurement: Questionnaire. Levels of IL-6, CGRP and TAC. Timepoint: The beginning and the end of the study. Method of measurement: Laboratory method. Esfahan University of Medical Sciences Approved 2018-03-04 کمیته اخلاق دانشگاه علوم پزشکی اصفهان Isfahan University of medical science, Hezar Jarib Ave Isfahan Isfehan Iran (Islamic Republic of)