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IRCT138810193028N1 IRCT 2009-05-22 Kermanshah University of Medical Sciences (KUMS ) A comparative study of Clomiphene citrate and short course Anastrozole in intrauterine insemination cycles The comparative study of Clomiphene citrate and short course Anastrozole in intrauterine insemination cycles 2009-05-22 anticipated 60 Complete https://irct.ir/trial/3011 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 2 Unexplained infertile women undergoing IUI treatment. Intervention 1: In case group: Anastrozole tablets 1 mg / once daily/ for three days, from days3-5 of menstrual cycle and followed by gonadotropines from days 6-8. Intervention 2: In control group: Clomiphene citrate tablets 50 mg orally, two tablets per day, from days 3-7 and followed by gonadotropins from days 6-8.
public Dr, Taravat Fakheri
Obs & Gynecology department, Imam Reza Hospital, Parastar Blvd, Sorkheh Lyjeh
Kermanshah Iran (Islamic Republic of) 67144-15333 +98 83 1427 6310 fakheritaravats@yahoo.com Kermanshah University of Medical Sciences ( KUMS) scientific Dr.Salma Hosseini
Obs & Gynecology department, Imam reza hospital, Parastar blvd, Sorkheh lyjeh
Kermanshah Iran (Islamic Republic of) 67144-15333 +98 83 1427 6310 sara_daee@yahoo.com Kermanshah University of Medical Sciences ( KUMS) Iran (Islamic Republic of) Inclusion criteria: 1) to have at least 12 months of infertility; 2) unexplainable infertility; 3) regular period cycles between 21 to 35 days. Exclusion Criteria: 1) women younger than 18 and older than 38 years old; 2) anovulation; 3) prior ART cycles; 4) systemic diseases such as endometriosis, persistent ovarian cyst and malignancies of breast, ovary and uterine. Basic alternatives such as age and BMI are measured and both groups regarding the alternatives will be matched. 18 years 38 years Female N97.9 Female infertility, unspecified Treatment - Drugs Treatment - Drugs In case group: Anastrozole tablets 1 mg / once daily/ for three days, from days3-5 of menstrual cycle and followed by gonadotropines from days 6-8 In control group: Clomiphene citrate tablets 50 mg orally, two tablets per day, from days 3-7 and followed by gonadotropins from days 6-8 Numbers and size of adult foliclles after one treatment cycle. Timepoint: In every stimulation cycle , in the Ninth day of cycle. Method of measurement: By means of vaginal sonography. Thickness of endometerium after a period of treatment. Timepoint: In every ovulatory cycle in the ninth day of cycle. Method of measurement: By means of vaginal sonography. Kermanshah University of Medical Sciences (KUMS ) Approved Kermanshah University of Medical Sciences Obs & Gynecology department, Imam Reza Hospital, Parastar Blvd Kermanshah Iran (Islamic Republic of)