]>
IRCT20150629022965N14 IRCT 2018-04-21 Hamedan University of Medical Sciences Effect of high dose oral Acetyl-L-carnitine on ischemic stroke Comparison of the effect of high dose oral Acetyl-L-carnitine and placebo on serum level of inflammatory cytokines in patients with ischemic stroke: a double-blind randomized clinical trial 2018-03-20 anticipated 90 Complete https://irct.ir/trial/30143 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: The patients will be randomly assigned to intervention and control groups using block randomization, Blinding description: Patients will be unaware of the type of intervention. The physician who will examine the patients will not be aware of the intervention. Therefore, the trial will be run as double-blind. 2 ischemic stroke. Intervention 1: Control group: In the control group, patients will receive placebo at the dose of 1 g, three times a day (every 8 hours) for 3 days in addition to the standard treatment. Intervention 2: Intervention group: In the intervention group, patients will receive oral Acetyl-l-Carnitine, one 500mg capsule, at the dose of 1 g three times a day (every 8 hours) for 3 days in addition to the standard treatment. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information
public Maryam Mehrpooya
Pharmacy school,Hamadan University of Medical Sciences,in front of Mardom park,Shahid Fahmideh Blvd,Hamedan
Hamedan Iran (Islamic Republic of) 6517838678 +98 81 3838 0717 m_mehrpooya2003@yahoo.com Hamedan University of Medical Sciences scientific Maryam Mehrpooya
Pharmacy school, Hamedan University of Medical Sciences, in front of Mardom park, Shahid Fahmideh Blvd. Hamedan
Hamedan Iran (Islamic Republic of) 6517838678 +98 81 3838 0717 m_mehrpooya2003@yahoo.com Hamedan University of Medical Sciences Iran (Islamic Republic of) age 18 to 85 years focal neurological disorder Clinical diagnosis of hemispheric acute ischemic stroke Radiological findings in MRI and CT scan consistent with clinical diagnosis of acute hemispheric stroke No other inflammatory disease at same time Not using other drugs that alter the level of outcomes of this study no Pregnancy and lactation Patients who have been admitted for the first 24 hours after the stroke. Patients who have had an ischemic stroke for the first time. 18 years 85 years Both Existing evidence show acute or chronic intracerebral hemorrhage and brain aneurysm The presence of any other etiology except ischemia The presence of any cognitive or behavioral impairment that leads to a patient's lack of cooperation I63 Cerebral infarction Placebo Treatment - Drugs Control group: In the control group, patients will receive placebo at the dose of 1 g, three times a day (every 8 hours) for 3 days in addition to the standard treatment. Intervention group: In the intervention group, patients will receive oral Acetyl-l-Carnitine, one 500mg capsule, at the dose of 1 g three times a day (every 8 hours) for 3 days in addition to the standard treatment. Serum level of IL-6. Timepoint: before intervention and 3 days after intervention. Method of measurement: ELISA kit. Serum level of TNF-alpha. Timepoint: before intervention and 3 days after intervention. Method of measurement: ELISA kit. Serum level of NSE. Timepoint: before intervention and 3 days after intervention. Method of measurement: ELISA kit. Serum level of ICAM-1. Timepoint: before intervention and 3 days after intervention. Method of measurement: ELISA kit. Side effects. Timepoint: 3 days after intervention. Method of measurement: Clinical examination. Hamedan University of Medical Sciences Approved 2018-03-09 Ethics committee of Hamedan University of Medical Sciences School of Pharmacy, Hamedan University of Medical Sciences, in front of Mardom park, Shahid Fahmide boulevard Hamedan Hamadan Iran (Islamic Republic of)