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IRCT20080831001138N27 IRCT 2018-05-09 Rasht University of Medical Sciences Effect of Matricaria Chamomilla on Quality of Life in Patients with Chronic Rhinosinusitis Evaluation of the Effect of Matricaria Chamomilla on Quality of Life in Patients with Chronic Rhinosinusitis Referred to Amiralmounin Hospital in Rasht 2018-02-22 anticipated 74 Complete https://irct.ir/trial/30160 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Other design features: The clinical trial has two groups of cases and controls, Randomization description: In this way at first, before the start of the study, the Random Allocation software gives a list of random numbers that is evenly divided into two groups A and B to a third party, each of them in separate closed envelopes according to the list. If the patient is referred to and qualified, one of the envelopes is given to the patient according to the number and after filling the forms, the envelope is opened and the patient is placed in one of the groups and receives the corresponding medication. Patients will not inform about the received medication, Blinding description: In order to maintain blindfolded of the study, both patients and researchers associated with patients will be unaware of the patient's drug intake (in the clinic, one researcher will distribute and record the drug to the patient, and the other researcher will evaluate the patients. Medications will look quite similar in shape, color and size. 3 Chronic rhinosinusitis. Intervention 1: Intervention group: In this study, chamomile extract was prepared by maceration method. Patients use 3 drops of the extract in each nostril after washing each nostril with 10 cc normal saline three times a day. Intervention 2: Control group: washes the nose with 10 cc normal saline in each nostril three times a day then uses sesame seed oil as a placebo and three drops per nostril. All patients will be taught how to properly use drug and nasal washing. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information
public Dr Shadman Nemati
Amiralamomenin Hospital, 17 Shahrivar St
Rasht Iran (Islamic Republic of) 41396-37459 +98 13 1222 5242 nemati@gums.ac.ir Rasht University of Medical Sciences scientific Dr Shadman Nemati
Amiralamomenin Hospital, 17 Shahrivar St
Rasht Iran (Islamic Republic of) 41396-37459 +98 13 1222 5242 nemati@gums.ac.ir Rasht University of Medical Sciences Iran (Islamic Republic of) Age over 18 years old Having at least reading and writing skills Having chronic rhinosinusitis according to the diagnosis of ENT 18 years no limit Both Pregnancy History of sinus and nasal surgery Usage of corticosteroid drugs continuously and daily History of nasal polyp Lund-Mackay scores above 14 in sinus CT Rhinosinusitis Chronic exacerbation requires antibiotics History of any sensitivity to chamomile or its compounds Usage of drugs such as ciclosporin, aspirin, warfarin and heparin J32 Chronic sinusitis Treatment - Drugs Placebo Intervention group: In this study, chamomile extract was prepared by maceration method. Patients use 3 drops of the extract in each nostril after washing each nostril with 10 cc normal saline three times a day Control group: washes the nose with 10 cc normal saline in each nostril three times a day then uses sesame seed oil as a placebo and three drops per nostril. All patients will be taught how to properly use drug and nasal washing Quality of life. Timepoint: Before the treatment, the first week, second week, third week. Method of measurement: Information obtained from the Sino-Nasal Outcome Test (SNOT-22) Questionnaire and biographies. Rasht University of Medical Sciences Approved 2018-03-03 Ethics committee of Guilan University of Medical Sciences vice-chancellor for Research Building, opposite of Sepah Bank,Shahid Beheshti Blvd Rasht Guilan Iran (Islamic Republic of)