IRCT20150302021294N7 IRCT 2018-03-22 Semnan University of Medical Sciences effect of Transcranial Direct current Stimulation on fatigue and quality of life in multiple sclerosis Comparative effect of Dorso lateral prefrontal cortex Transcranial Direct Current Stimulation and Primary Motor Cortex Transcranial Direct Current Stimulation on fatigue in the patients with multiple sclerosis 2018-05-22 anticipated 45 Complete https://irct.ir/trial/30200 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: simple randomization,individual,random number table,randomized permutation blocks(block3), using excel software to generate random number tables, Blinding description: All of participants are blind to type of intervention and assessors are blind to type of intervention and experimental conditions. 0 (exploratory trials) multiple sclerosis. Intervention 1: Intervention group:First intervention group: transcranial direct current stimulation on dorsolateral prefrontal group with 20 min Exposure duration 1.5 mA. Intervention 2: Intervention group:Direct electrical stimulation of motor area for 20 minutes with an intensity of 1.5 mA. Intervention 3: Control group: The sham group was placed by placing the electrode on the motor or perforontal region by randomly actuating 30 seconds at the beginning of the treatment and being off until the end of the 20 minute treatment. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is no more uinformation