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IRCT20131219015870N3 IRCT 2018-06-10 Faculty of Pharmaceutical Sciences, Islamic Azad University of Medical Sciences, Tehran The effect of silymarin on Alzheimer’s diseases The effect of silymarin on inflammatory factors TNF-α and IL-1β and it’s probable relationship with cognitive function of Alzheimer’s patients. 2018-02-24 anticipated 22 Complete https://irct.ir/trial/30271 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment, Other design features: Patients' drug regimens do not change at the time of entry, and only silymarin is added to their medication regimen. 4 Alzheimer disease. Intervention group: daily 3 tablets of 140 mg silymarin for 3 months. Yes - There is a plan to make this available What will be shared: The total potential data can be shared after unidentifiable people When: Start the access period one year after the print results To whom: Only for researchers working in academic and scientific institutions Conditions: if The disclosure of requested information does not disturb other research related to this research Where to obtain: By Dr. Amir Kiani's email Kermanshah University of Medical Sciences: akiani@kums.ac.ir How to obtain: The publisher send email to the principal responsible person, And the principal will respond to the publisher after checking, then this response will be passed from the publisher to the requesting person Comments:
public Dr amir kiani
Parastar blvd, Kermanshah University Medical Science
Kermanshah Iran (Islamic Republic of) 6734667149 +98 83 3427 6493 akiani@kums.ac.ir Kermanshah University of Medical Sciences scientific Dr amir kiani
Parastar Blvd, Kermanshah University of Medical Science
Kermanshah Iran (Islamic Republic of) 6734667149 +98 83 3427 6493 akiani@kums.ac.ir Kermanshah University of Medical Sciences Iran (Islamic Republic of) Patients who diagnosed with brain imaging and biochemical tests, Alzheimer's by a neurologist no limit no limit Both epilepsy heart failure CKD hypothyroidism vitamon b 12 deficiency psychiatric desease stroke brain tumor hydrocephaly encephalitis pragnancy excerbation of symptoms when patiants want to start silymarin G30 Alzheimer's disease Treatment - Drugs Intervention group: daily 3 tablets of 140 mg silymarin for 3 months Score of cognitive function in Mini Mental State Examination. Timepoint: At the beginning of the study (before the intervention) and 3 months later. Method of measurement: Mini Mental State Examination. Serum levels of TNF-α inflammatory factor. Timepoint: At the beginning of the study (before the intervention) and 3 months later. Method of measurement: ELISA. Serum levels of IL-1β inflammatory factor. Timepoint: At the beginning of the study (before the intervention) and 3 months later. Method of measurement: ELISA. Kermanshah University of Medical Sciences Faculty of Pharmaceutical Sciences, Islamic Azad University of Medical Sciences, Tehran Kermanshah university of Medical Science Approved 2017-02-01 Ethics Committee in the research of Pharmaceutical Sciences Branch of Islamic Azad University Pharmaceutical Sciences Branch of Islamic Azad University, Yakhchal ave,Gholhak tehran Tehran Iran (Islamic Republic of)