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IRCT20180327039152N1 IRCT 2018-04-28 Ilam University of Medical Sciences Effects of Scrophularia striata Extract on Recurrent aphthous stomatitis recovery Effects of Scrophularia striata Extract on pain relief aphthous stomatitis 2018-04-06 anticipated 100 Complete https://irct.ir/trial/30316 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: We use the random block randomization method.In this way, we will produce eight paper sheets. we write on the two sheetof the letter I1 means Intervention 1(Solution 10%), On the two sheetof the letter I2 means Intervention 2(Solution 15%), On the two sheetof the letter C1 means Control1(Diphenhydramine syrup), On the two sheetof the letter C2 means Control2(Salin serum), Blinding description: Mix the sheets together and place them in the drawer.By referring to each eligible patient, one of the sheets is drawn randomly. Based on this drawn sheet (I1, I2 or C1, C2), they will be assigned to one of the two intervention or control groups.It should be noted that the drawn sheets will not be returned to the drawer until all eight papers have been drawn out.after having drawn out randomly every eight sheets,all sheets are returned to drawer again and the above action again for the next eight to reach the desired sample size will continue. 3 Recurrent aphthous stomatitis. Intervention 1: Intervention group: First: 10% solution. Intervention 2: Intervention group:second: 15% solution. Intervention 3: Control group: First: Diphenhydramine syrup. Intervention 4: Control group: second: Salin serum. No - There is not a plan to make this available Justification or reason for not sharing IPD is Adherence to the principles of ethics in research
public Masoumeh Shohani
Pazhohesh Blv.
Ilam Iran (Islamic Republic of) 6939177143 +98 84 3222 7114 shohani-m@medilam.ac.ir Ilam University of Medical Sciences scientific Masoumeh Shohani
Pazhohesh Blv.
Ilam Iran (Islamic Republic of) 6937177143 +98 84 3222 7114 shohani-m@medilam.ac.ir Ilam University of Medical Sciences Iran (Islamic Republic of) Definitive diagnosis of minor oral aphthous by specialist dentistry Life span is 3 days or less. Age over 7 years. 7 years no limit Both Children under 7 years of age and those who are nervous and anatomical can not gargle Pregnancy Atypical cases of pests and cases suspected of Behcet's syndrome, Inflammatory bowel disease, or history of any type of underlying illness that can predispose a person to aphthous . Drug and tobacco use Taking effective medications for wound healing, such as corticosteroids, anticoagulants, immunosuppressive drugs, chemotherapy Concomitant use of any topical drug for the treatment of aphthous The use of any type of topical or systemic analgesic, Use of any systemic pest treatment over the past 3 months K12.0 Recurrent oral aphthae Treatment - Drugs Treatment - Drugs Placebo Placebo Intervention group: First: 10% solution Intervention group:second: 15% solution Control group: First: Diphenhydramine syrup Control group: second: Salin serum Pain relief for recurrent oral aphthous. Timepoint: At the first meeting with the participants and days 1, 2, 3, 5 and 7 after starting treatment. Method of measurement: use of visual analog scale(VAS). Wound healing rate. Timepoint: Admission and days 3 and 7. Method of measurement: Measuring the wound using a periodontal probeŁˆ in millimeters. The rate of recurrence of ulcers. Timepoint: Up to three months monthly. Method of measurement: Questions about the recurrence of ulcers by phone. Ilam University of Medical Sciences Approved 2018-04-07 Ethics committee of Ilam University of Medical Sciences Pazhohesh blv. Ilam Ilam Iran (Islamic Republic of)