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IRCT20100427003813N7 IRCT 2018-05-17 Babol University of Medical Sciences Clinical and radiographic evaluation of applying 1.2% Atorvastatin gel with plasma rich in growth factor (PRGF) for treatment of class II furcation involvement Clinical and radiographic evaluation of applying 1.2% Atorvastatin gel with plasma rich in growth factor (PRGF) for treatment of class II furcation involvement 2017-05-27 anticipated 24 Complete https://irct.ir/trial/30474 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple randomization, Blinding description: Patients are classified in the intervention group with knowledge of the entire study and informed consent form. The outcome elevator measures the study data without any knowledge about type of treatment. 3 furcation grade 2 involvement of lower jaw molars. Intervention 1: intervention group 1: Using Atorvastatin1.2% alone in treatment of 6 mandibular molar grade II furcation involvment. Intervention 2: Intervention group 2: use of Atorvastatin1.2% plus PRGF in treating 6 mandibular molar grade II furcation involvment. Intervention 3: Intervention group 3: Use of PRGF alone in treating 6 mandibular molar grade II furcation involvment. Intervention 4: Control group: Debridement alone in treating 6 mandibular molar grade II furcation involvment. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is no more information
public Niloofar Jenabian
Babol Dental University, Ganjafroz Ave, Babol
Babol Iran (Islamic Republic of) 4717647745 +98 11 1229 1408 n.jenabian@mubabol.ac.ir Babol University of Medical Sciences scientific Niloofar Jenabian
Babol Dental University. Ganjafroz Ave, Babol
Babol Iran (Islamic Republic of) 47176-47745 +98 11 1229 1408 n.jenabian@mubabol.ac.ir Babol University of Medical Sciences Iran (Islamic Republic of) Patients with moderate to severe chronic periodontitis with severe grade II fractures on the buccal or lingual side of the first or second mandibular molars The horizontal probing depth of the probes in the affected areas is greater than or equal to 3mm no limit no limit Both Systemic disease The need for prophylactic antibiotics to prevent bacterial endocarditis Use of intermittent drugs with periodontal improvement smoking presence of contraindication for periodontal surgery dental anatomical complications such as accessory canal concavity CEP, bifurcation ridge Tooth mobility more than Grade II The presence of decay and filling in the area of ​​forcation There is evidence of periapical pathology in the clinical or radiographic view of the tooth Possibility of unaccompanied consent after initial periodontal treatment Treatment - Surgery Treatment - Surgery Treatment - Surgery Treatment - Surgery intervention group 1: Using Atorvastatin1.2% alone in treatment of 6 mandibular molar grade II furcation involvment Intervention group 2: use of Atorvastatin1.2% plus PRGF in treating 6 mandibular molar grade II furcation involvment Intervention group 3: Use of PRGF alone in treating 6 mandibular molar grade II furcation involvment Control group: Debridement alone in treating 6 mandibular molar grade II furcation involvment Grade 2 furcation involvement of lower jaw molars. Timepoint: Immediately before surgery 3 and 6 months after surgery. Method of measurement: periodontal probe. Babol University of Medical Sciences Approved 2017-06-18 Babol University of Medical Sciences, Dept. of Research and Technology University of Medical Sciences, Dept. of Research and Technology Ganjafroz Ave, Babol Babol Mazandaran Iran (Islamic Republic of)