]>
IRCT20171015036782N6 IRCT 2018-10-07 Yazd University of Medical Sciences Effect of herbal medicine, Resveratrol, on gingival infection Comparing the effect of Resveratrol supplementation and standard treatment on clinical parameters and inflammatory markers in the patients with chronic periodontitis 2018-04-09 anticipated 40 Complete https://irct.ir/trial/30532 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients are divided into control and intervention groups using a random-number table, Blinding description: In this study, the participants and the investigator will not be aware of the type of prescribed drug. N/A moderate to severe chronic periodontitis. Intervention 1: Intervention group: Non-surgical periodontal treatment and daily administration of resveratrol 480 mg capsule, produced by Herbafit company (Germany) for 4 weeks. Intervention 2: Control group: non-surgical periodontal treatment and daily administeration of placebo 480 mg capsule (containing starch) for 4 weeks. Yes - There is a plan to make this available What will be shared: The whole data is shared When: Six months after the publication of the article To whom: Researchers working in academic institutions Conditions: Email, Call Where to obtain: Shabnam Nikniaz, 09144901929, sh.nikniaz@gmail.com How to obtain: After sending the Email, the data will be transmitted Comments:
public Shabnam Nikniaz
P4, Yas complex, Javadolaeme, Safayieh
Yazd Iran (Islamic Republic of) 8915873948 +98 914 490 1929 sh.nikniaz@gmail.com Yazd University of Medical Sciences scientific Shabnam Nikniaz
P4, Yas complex, Javadolaeme, Safayieh
Yazd Iran (Islamic Republic of) 8915873948 +98 914 490 1929 sh.nikniaz@gmail.com Yazd University of Medical Sciences Iran (Islamic Republic of) age between 30 to 60 years old chronic moderate to severe periodontitis 30 years 60 years Both Pregnancy Breast feeding Traveling for more than 2 weeks Smoking Using immunosuppressive medications Using NSAIDs Using anti hypertension drugs or Medications that slow blood clotting such as warfarin Using insulin Affecting by uterine cancer, breast cancer or ovarian cancer or being under cancer treatment Advanced kidney and liver problems Allergy to black grapes or blueberry Periodontal treatment history during the past 6 months Considerable changes in diet over the past 6 months K05.3 Chronic periodontitis Treatment - Drugs Placebo Intervention group: Non-surgical periodontal treatment and daily administration of resveratrol 480 mg capsule, produced by Herbafit company (Germany) for 4 weeks Control group: non-surgical periodontal treatment and daily administeration of placebo 480 mg capsule (containing starch) for 4 weeks. Probing depth. Timepoint: Beggining of study and 1 month later. Method of measurement: Williams probe. Clinical Attachment Loss. Timepoint: Beggining of study and 1 month later. Method of measurement: Using the Williams probe. Plaque Index. Timepoint: Beggining of study and 1 month later. Method of measurement: By colloring with disclosing pills and calculating the percentage of whole mouth. Bleeding Index. Timepoint: Beggining of study and 1 month later. Method of measurement: Checking Bleeding on probing in the mouth and measuring its percentage. The level of IL-8 in saliva. Timepoint: Beggining of study and 1 month later. Method of measurement: Eliza kit. The level of IL-1β in saliva. Timepoint: Beggining of study and 1 month later. Method of measurement: Eliza kit. Yazd University of Medical Sciences Approved 2018-02-26 Ethics committee of Yazd University of Medical Sciences P4, Yas complex, Javadolaeme, Safayieh Yazd Yazd Iran (Islamic Republic of)