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IRCT20180408039225N1 IRCT 2018-06-02 Yazd University of Medical Sciences Synchronization of metformin with sitagliptin on the expression of` miRNA21, 223 in insulin resistant human adipocyte tissue and serum Synchronization of metformin with sitagliptin on the expression of` miRNA21, 223 in insulin resistant human adipocyte tissue and serum 2018-04-04 anticipated 30 Complete https://irct.ir/trial/30548 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Health service research. 3 Insulin resistance. Intervention 1: Intervention group: Fat persons with insulin resistance. Division to two groups: one for treat with metformin , and other for treat with metformin and sitagliptin for 2-3 months, than take serum and adipose tissue and determination of level of miRNAs expression with RT_PCR method and compare with together. Intervention 2: Control group: Non fat person without insulin resistance without consumption of drug and take serum and adipose tissue and determination of level of miRNAs expression with RT_PCR method. Yes - There is a plan to make this available What will be shared: synchronization of metformin with sitagliptin on the expression of` miRNA21,223 in insulin resistant human adipocyte tissue and serum When: there is not time period To whom: everybody Conditions: in diabetes researchs Where to obtain: in e-mail address:yosofnaghiaee@yahoo.com How to obtain: sendig an e-mail to responsible proposal Comments:
public Naghiaee,Yousof
Emam hossein square_Emam Reza complex
Yazd Iran (Islamic Republic of) 8916188637 +98 35 3168 2105 yosofnaghiaee@yahoo.com Yazd University of Medical Sciences scientific Naghiaee,Yousof
Emam Hosein square_Emam Reza complex
Yazd Iran (Islamic Republic of) 8916188637 +98 35 3168 2105 yosofnaghiaee@yahoo.com Yazd University of Medical Sciences Iran (Islamic Republic of) Everybody as diabetic for the first time and new case was selected, and if have HOMA index more than 1.5 are case group and less than 1.5 are control group. no limit no limit Both Everybody as diabetic or used to diabetic drugs or insulin and everybody had hormone therapy or with endocrine disorders, persons with renal disorders and cancer or malignant tumors and had chemotherapy are deleted from survey. Diagnosis Diagnosis Intervention group: Fat persons with insulin resistance. Division to two groups: one for treat with metformin , and other for treat with metformin and sitagliptin for 2-3 months, than take serum and adipose tissue and determination of level of miRNAs expression with RT_PCR method and compare with together. Control group: Non fat person without insulin resistance without consumption of drug and take serum and adipose tissue and determination of level of miRNAs expression with RT_PCR method. MiRNA changes. Timepoint: First -End. Method of measurement: RT_PCR method. Yazd University of Medical Sciences Approved 2017-05-23 Moral in Biomedical Researches Bahonar square_Central Organization of Shahid Sadughi University Yazd Yazd Iran (Islamic Republic of)