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IRCT20100427003813N8 IRCT 2018-06-29 Babol University of Medical Sciences the effect of chitosan in periodontal intra bony defect Clinical and radiographic evaluation of chitosan particles in treatment of periodontal intra bony defect 2016-05-21 anticipated 18 Complete https://irct.ir/trial/30556 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: The randomization scheme was 1:1:1 (2cases groups and 1 control group). Randomization was stratified by clinical trial site. The unblinded trial statistician generated randomization sequences (block randomization with block size of eight) and the unblinded clinical trial staff assigned each participant to a treatment group, Blinding description: Patients do not aware of treatment group which they included The evaluater is different from surger and she is blind. 3 Chronic periodontitis. Intervention 1: Intervention group : open flap debridement with chitosan with high molecular weight (MW800000-600000). Intervention 2: Intervention group: open flap debridement with chitosan with low molecular weight (MW300000-100000). Intervention 3: Control group: Open flap debridement. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information
public Niloofar Jenabian
Ganjafrooz Ave.
Babol Iran (Islamic Republic of) 4717647745 +98 11 3220 7918 n.jenabian@mubabol.ac.ir Babol University of Medical Sciences scientific Niloofar Jenabian
Ganjafrooz Ave.
Babol Iran (Islamic Republic of) 4717647745 +98 11 3220 7918 n.jenabian@mubabol.ac.ir Babol University of Medical Sciences Iran (Islamic Republic of) The entry requirements were presence of 3-walled intrabony defects in buccal or lingual sides of upper or lower first or second premolar or molars. plaque index under 20 between 30 - 50 years old 30 years 50 years Both systemic disease taking any drugs interfering with periodontal wound healing smokers presence of any periodontal surgery contraindications teeth with anatomical complications such as cervical enamel projections; bifurcation ridge; accessory canal and concavity presence of hemi septal bony defects presence of caries in the root of teeth adjacent to the intrabony defect K05.3 Chronic periodontitis Treatment - Surgery Treatment - Surgery Treatment - Surgery Intervention group : open flap debridement with chitosan with high molecular weight (MW800000-600000) Intervention group: open flap debridement with chitosan with low molecular weight (MW300000-100000) Control group: Open flap debridement Clinical attachment level. Timepoint: at the begining of study and immediately before surgery, 6 and 12 months after sergury. Method of measurement: with periodontal probe. Probing depth. Timepoint: at the begining of study and immediately before surgery, 6 and 12 months after sergury. Method of measurement: with perodontal probe. Radiographic Defect Depth. Timepoint: at the begining of study and immediately before surgery, 6 and 12 months after sergury. Method of measurement: parallel technic by means of digital sensor size 2(Soredex.Helsinki-finland)by Rinndentsply film holder. Babol University of Medical Sciences Approved 2016-06-15 Ethics committee of Babol univercity of medical science Ganjafrooz Ave. Babol Mazandaran Iran (Islamic Republic of)