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IRCT20130518013366N10 IRCT 2018-07-25 Arak University of Medical Sciences Effect of Ibuprofen and Acetaminophen in Cardiac Vessels of Children Evaluation Effectiveness of Ibuprofen and Acetaminophen in Closure of Patent Ductus Arteriosus 2018-05-21 anticipated 80 Complete https://irct.ir/trial/30638 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: In order to randomization we will use the block method, Accordingly, the patients under study are divided into two groups. The allocation of patients in two groups was based on demographic characteristics and their matching. Based on this, after considering the patients' demographic data, patients were divided into two equal groups of patients, they enrolled in the study and performed desired intervention on them, Blinding description: This means that patients in groups do not know the used drugs, and drugs has similar packaging. 4 Patent Ductus Arteriosus. Intervention 1: Intervention group: Oral ibuprofen ten milligrams per kilogram of body weight per day, for three days. Intervention 2: Intervention group: Oral acetaminophen seven milligrams per kilogram of body weight per day, for 3 days. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information
public Yazdan Ghandi
3819693345, Amir-Kabir Hospital, Basij Square, Arak.
Arak Iran (Islamic Republic of) 3819693345 +98 86 3313 5075 drghandi151@gmail.com Arak University of Medical Sciences scientific Dr. Parsa Yousefichaijan
3819693345, Amir-Kabir Hospital, Basij Square, Arak.
Arak Iran (Islamic Republic of) 3819693345 +98 86 3313 5075 parsayousefichaijan@yahoo.com Arak University of Medical Sciences Iran (Islamic Republic of) Infants less than 28 days old referring to Amir Kabir Hospital with Patent Ductus Arteriosus Parental consent for participation in the study No G6PD Enzymatic Deficiency no limit 28 days Both Dissatisfaction with using their information in the study Neonates with congenital heart defects that Patent Ductus Arteriosus were life giving, such as pulmonary artery atresia, congenital or chromosomal major abnormalities, the history of using non-steroidal anti-inflammatory drugs during pregnancy by mother, the presence of Hydrops Fetalis, and a continuous increase in Pulmonary Blood Pressure. Leaving the hospital with personal consent Q25.0 Patent ductus arteriosus Treatment - Drugs Treatment - Drugs Intervention group: Oral ibuprofen ten milligrams per kilogram of body weight per day, for three days Intervention group: Oral acetaminophen seven milligrams per kilogram of body weight per day, for 3 days Patent Ductus Arteriosus Closure Status. Timepoint: Before intervention for diagnosis and within three days interval of starting the drug. Method of measurement: Echocardiography. Arak University of Medical Sciences Approved 2018-02-26 Ethics committee of Arak University of Medical Sciences Sardasht Arak Markazi Iran (Islamic Republic of)