IRCT20111123008177N18 IRCT 2018-09-18 Iran University of Medical Sciences Needling technique with topical Latanoprost in treatment of hypopigmented burn scars Investigating the effectiveness of needling technique with topical Latanoprost in treatment of hypopigmented burn scars in burn patients 2018-09-23 anticipated 30 Complete https://irct.ir/trial/30737 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Other design features: Patients in both groups (A) and (B) are treated in one limb and untreated in the other limb. Therefore, each intervention group will have a control group, Randomization description: Patients who have the inclusion criteria are enrolled in the study. Assigning the treatment type to either of the two same areas is done by simple randomization by software, Blinding description: To do blinding process, the placebo drops similar to those of Latanoprost are prepared and used simultaneously with the same dose. Patients who participate, main researchers of the study, dermatologist who perform the microneedling technique, the plastic surgeon examining the outcome of patient's scar before and after the intervention, and ultimately the person who is analyzing the data are blind to the study. 2-3 Hypopigmented scar. Intervention 1: Intervention group 1: Needling procedure is performed under local anesthesia on the hypopigmented or depigmated organs of the patient, measuring from 4 to 25 cm square. The German AMIEA MED microneedling is a DA-3.0-EN-MP type approved by CE Europe, ISO 13485, and the Ministry of Health. Then, a drop of latanoprost (0.005%, 50 μg / ml, Iran, Sina drug) is applied to the patient. The dose is one drop per 2 × 2 cm area twice daily for 24 weeks. Intervention 2: Intervention group 2: Needling procedure is performed under local anesthesia on the hypopigmented or depigmated organs of the patient, measuring from 4 to 25 cm square. Then placebo drops containing distilled water are used. The dose is one drop per 2 × 2 cm area twice daily for 24 weeks. Intervention 3: Control group: Symmetrical limb will be left untreated in each patient. No - There is not a plan to make this available Justification or reason for not sharing IPD is No more information