]>
IRCT20150815023617N4 IRCT 2018-07-03 National Nutrition And Food Technology Research Institute of Iran nanomicielles curcumin in metabolic syndrome The effects of nanomicielle curcumin on oxidative stress, systemic inflammation, adiponectin in serum and NF-kB in blood mononuclear cells, in patients with metabolic syndrome 2018-05-30 anticipated 23 Complete https://irct.ir/trial/30766 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: Supplements and placebo will be identified with codes A, B, and researchers do not know how the codes will be distributed. Then, from the table of four blocks(A and B), 13 blocks will be randomly selected, and these blocks will be placed behind each other. Then, 25 envelopes will be provided and the name of the group A or B put in each envelope . These envelopes will be referred to individuals, respectively, Blinding description: Supplements and placebo will be identified with codes A, B, and researchers do not know how the codes will be distributed. 3 Metabolic Syndrom. Intervention 1: Intervention group: Each capsule contains 80 mg nanomicielles curcumin. Use once a day for 12 weeks. Intervention 2: Control group: Each capsule contains yellow colour(E104) and lecithin. Use once a day for 12 weeks. Yes - There is a plan to make this available What will be shared: Only part of the data is shared, such as the original outcome. When: The start of the access period is 12 months after printing the results. To whom: It will be available for researchers working in academic and scientific institutions. Conditions: It will be available for researchers working in academic and scientific institutions. Where to obtain: golbonsohrab@sbmu.ac.ir zohre.bateni@yahoo.com How to obtain: The communication will be possible through the electronic mail given in the previous section. Comments:
public Golbon Sohrab
No. 7, West Hafezi Ave., Farahzadi Blvd., Qods Town
Tehran Iran (Islamic Republic of) 1981619573 +98 21 2236 0656 golbonsohrab@sbmu.ac.ir Shahid Beheshti University of Medical Sciences scientific Golbon Sohrab
No. 7, West Hafezi Ave., Farahzadi Blvd., Qods Town
Tehran Iran (Islamic Republic of) 1981619573 +98 21 2236 0656 golbonsohrab@sbmu.ac.ir Shahid Beheshti University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Tendency for participation Age between 18-70 years old BMI between 25-40 kg/m2 Having metabolic syndrome according to the NCEP ATP III definition(if patient have three or more of the following five criteria): waist circumference over 120 cm (men) or 89 cm (women), blood pressure over 130/85 mmHg, fasting triglyceride (TG) level over 150 mg/dl, fasting high-density lipoprotein (HDL) cholesterol level less than 40 mg/dl (men) or 50 mg/dl (women) and fasting blood sugar over 100 mg/dl. 18 years 70 years Both E88.81 Metabolic syndrome Treatment - Other Placebo Intervention group: Each capsule contains 80 mg nanomicielles curcumin. Use once a day for 12 weeks. Control group: Each capsule contains yellow colour(E104) and lecithin. Use once a day for 12 weeks. Adiponectin. Timepoint: Baseline and end of the study. Method of measurement: ELISA method. Total Antioxidant Capacity(TAC). Timepoint: Baseline and end of the study. Method of measurement: Enzymatic colorimetric analysis method. Malondialdehyde(MDA). Timepoint: Baseline and end of the study. Method of measurement: Enzymatic colorimetric analysis method. High-sensitivity C-reactive protein(hs-CRP). Timepoint: Baseline and end of the study. Method of measurement: ELISA method. Nuclear factor-κB. Timepoint: Baseline and end of the study. Method of measurement: ELISA method. National Nutrition And Food Technology Research Institute of Iran Approved 2018-02-09 Ethics committee of Shahid Beheshti University of Medical Sciences No. 7, West Hafezi Ave., Farahzadi Blvd., Qods Town Tehran Tehran Iran (Islamic Republic of)