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IRCT20180422039383N1 IRCT 2019-01-26 Shiraz University of Medical Sciences Study of the effect of selenium on myocardial protection Effect of selenium added to the cardioplegic solution on cardiac protection in coronary artery bypass grafting surgeries And the comparison with the control group 2017-06-21 anticipated 66 Complete https://irct.ir/trial/30829 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Other, Purpose: Treatment, Randomization description: Patients were randomly divided into control and intervention groups using random numbers table, Blinding description: Patients did not have any information about the type of intervention and the intervention was performed during anesthesia and no information was given to the patient prior to anesthesia. And the information is completed by caregivers. After collecting information by a caregiver, this information is analyzed by a statistic expert. 3 Coronary Artery Bypass Graft Surgery. Intervention 1: Intervention group: Adding 1000 microgram Selenium (Sodium selenite) to Cardioplegic Solution. The cardiopulmonary solution is then injected into the coronary arteries. Intervention 2: Control group: Adding 20 cc normal saline to cardioplegic solution. The cardiopulmonary solution is then injected into the coronary arteries. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is I have not decided yet
public Masih Shafa
Opposite the Palestine Street, Zand Street,Shiraz
Shiraz Iran (Islamic Republic of) 7134814336 +98 71 3230 5410 masooda1361@gmail.com Shiraz University of Medical Sciences scientific Masih Shafa
Namazi hospital, Namazi square, Zand Street
Shiraz Iran (Islamic Republic of) 7193711351 +98 71 3647 4332 masooda1361@gmail.com Shiraz University of Medical Sciences Iran (Islamic Republic of) Company satisfaction in research design EF more than 30% Age over 35 and under 80 Patients referred to the heart surgery room for CABG operation in government hospitals affiliated to Shiraz University of Medical Sciences. 35 years 79 years Both Combination and redo surgery History of recent infarction (less than a week) pregnancy High troponin level (greater than 3μgl / lit /) Treatment - Drugs Placebo Intervention group: Adding 1000 microgram Selenium (Sodium selenite) to Cardioplegic Solution. The cardiopulmonary solution is then injected into the coronary arteries. Control group: Adding 20 cc normal saline to cardioplegic solution. The cardiopulmonary solution is then injected into the coronary arteries. Cardiac Troponin marker: The most specific marker for heart damage. Timepoint: Troponin: at pre-operative intervals, immediately after surgery, 6 and 24 hours after surgery. Method of measurement: Troponin: Vidas Laboratory tool. Arrhythmia :It is called a disturbance in the normal rhythm of the heart and a symptom of a disorder in the normal functioning of the heart. Timepoint: From the de-clamping of aorta until the patient is delivered to the ICU. Method of measurement: Monitoring of arrhythmias using cardiac monitoring and eye care. Drug use and DC shock: The use of medication and DC shock indicates the severity of the risk and the risk of arrhythmia, which can be studied by comparing it in two groups. Timepoint: From the de-clamping of aorta until the patient is delivered to the ICU. Method of measurement: Through observation and review of the doctor's order in the patient file documents. Intra Aortic Ballon Pump : In a condition, the contractile power of the heart is not sufficient is used and increases the contractile power of the heart. Timepoint: After weaning of cardiopulmonary pump. Method of measurement: Doctor's order.Patient File Documentation. Blood Pressure. Timepoint: Before the operation, During the Cardiopulmonary Bypass, after cardiopulmonary bypass. Method of measurement: Arterial Line. Shiraz University of Medical Sciences Approved 2017-06-03 Ethics committee of Shiraz University of Medical Sciences the central building of Shiraz University of Medical Sciences, in front of the Felestine Street, Zand street, Shiraz. shiraz Fars Iran (Islamic Republic of)