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IRCT20180424039401N1 IRCT 2018-05-25 Mazandaran University of Medical Sciences evaluation of effect of bupivacaine and clonidine on pain control after laparoscopic cholecyctectomy comparison of the effectiveness of intraperitoneal bupivacaine with clonidine on reduction of pain after laparoscopic cholecyctectomy 2017-12-21 anticipated 78 Complete https://irct.ir/trial/30896 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: patient selection will do by pick a card from a boxe with 78card . 26card with for group1, 26kard for group2 and 26card fot group3. surgeon and patients are blined to the study, Blinding description: patients selection will carry by head nurse with pick up a card from a box with three type card(nubmer1, number2 and number3). patients and general surgeon are blinded to the patients group. oral drug or placebo will give to the patients by head nurse before surgery. intraperitoneal drug or placebo will manage by anesthesiologist. 3 Condition 1: acute cholecystitis. Condition 2: chronic cholecystitis. Condition 3: cholelithiasis. Intervention 1: Intervention group: intrapetoneal bupivacaine 0.5% 20cc. Intervention 2: Intervention group: 0.15 miligram tab clonidine 1.5 hour before surgery. Intervention 3: Control group: 20cc normal saline as plasebo. Intervention 4: Control group: tab piridoxine 40 miligeram. Yes - There is a plan to make this available What will be shared: . When: one week To whom: chief of study Conditions: . Where to obtain: . How to obtain: . Comments:
public Dr Nasrin Rahmani
Moalem avenue
Sari Iran (Islamic Republic of) 48178-43685 +98 11 3324 4496 farzad_mokhtari_s@yahoo.com Mazandaran University of Medical Sciences scientific Farzad Mokhtari
Moalem square
Sari Iran (Islamic Republic of) 48178-43685 +98 11 3324 4496 farzad_mokhtari_s@yahoo.com Mazandaran University of Medical Sciences Iran (Islamic Republic of) patients bethween 18-65years old with cholecyctitis patients bethween 18-65years old with symptomatic cholelithiasis 18 years 65 years Both patients with Allergy history to the aneshtetic agent severe cardiac disease severe lung disease patients with conversion to open cholecystectomy K80.0 K80.10 K80 Calculus of gallbladder with acute cholecystitis Calculus of gallbladder with chronic cholecystitis without obstruction Cholelithiasis Treatment - Drugs Treatment - Drugs Placebo Placebo Intervention group: intrapetoneal bupivacaine 0.5% 20cc Intervention group: 0.15 miligram tab clonidine 1.5 hour before surgery Control group: 20cc normal saline as plasebo Control group: tab piridoxine 40 miligeram Abdominal pain. Timepoint: 1 hour after operation. 6 hour after operation. 24 hour after operation. Method of measurement: visual analogue score. Pain killer consumption. Timepoint: during 24 hours after surgery. Method of measurement: computing pain killer consumption. Mazandaran University of Medical Sciences Approved 2018-03-18 Ethics committee of mazandaran University of Medical Sciences amirmazandarani street sari Mazandaran Iran (Islamic Republic of)