]>
IRCT20180506039558N1 IRCT 2018-07-28 Ahvaz University of Medical Sciences Intravenous Dexmedetomidine on Inflammatory Mediators in Patients candidate of Surgery Effect of Intravenous Dexmedetomidine on Inflammatory factors in Patients undergoing Total Abdominal Hysterectomy 2018-07-23 anticipated 40 Complete https://irct.ir/trial/31028 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple randomization with random number tables, Blinding description: Responsible for collecting data, data analyzer. 3 Abdominal Hysterectomy. Intervention 1: Intervention group: In the case group, immediately after the induction, Dexmedetomidine with a bolus dose of (1 μg/kg) during 15 minutes and infusion with a dose of (0.5 μg/kg) will be injected until the end of surgery. Intervention 2: Control group: In the control group, immediately after the induction, normal saline with a dose of (1 μg/kg) during 15 minutes and infusion with a dose of (0.5 μg/kg) will be injected until the end of surgery. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information
public Maryam Derakhshani
Azadegan Ave., Imam Khomeini Hospital
Ahvaz Iran (Islamic Republic of) 6135715794 +98 61329235893 derakhshani.m@ajums.ac.ir Ahvaz University of Medical Sciences scientific Shole Nesioonpour
Azadegan Ave., Imam Khomeini Hospital
Ahvaz Iran (Islamic Republic of) 6135715794 +98 61322235292 nesioon@gmail.com Ahvaz University of Medical Sciences Iran (Islamic Republic of) Female candidate of Total Abdominal Hysterectomy (TAH) Body mass index (BMI): 18 to 40 kg/m2 American Society of Anesthesiologists (ASA) classification I , II 35 years 65 years Female Allergic reaction to Dexmedetomidine History of Dexmedetomidine administration over the past week History of heart, lung, liver, and kidney diseases Patients with neurological or neuromuscular disorders Patients with anemia or bleeding disorders Consumption of Alcohol, narcotic and Antipsychotic medications Patients with diabetes Treatment - Drugs Treatment - Drugs Intervention group: In the case group, immediately after the induction, Dexmedetomidine with a bolus dose of (1 μg/kg) during 15 minutes and infusion with a dose of (0.5 μg/kg) will be injected until the end of surgery Control group: In the control group, immediately after the induction, normal saline with a dose of (1 μg/kg) during 15 minutes and infusion with a dose of (0.5 μg/kg) will be injected until the end of surgery Quantitative evaluation of C- Reactive Protein. Timepoint: 30 minutes before anesthesia induction (Before intervention), 1 hour after the start of operation, Immediately, 6 and 24 hours after the completion of the operation. Method of measurement: Blood test. Quantitative evaluation of ESR. Timepoint: 30 minutes before anesthesia induction (Before intervention), 1 hour after the start of operation, Immediately, 6 and 24 hours after the completion of the operation. Method of measurement: Blood test. Quantitative evaluation of Leukocytosis. Timepoint: 30 minutes before anesthesia induction (Before intervention), 1 hour after the start of operation, Immediately, 6 and 24 hours after the completion of the operation. Method of measurement: Blood test. Quantitative evaluation of Blood Glucose. Timepoint: 30 minutes before anesthesia induction (Before intervention), 1 hour after the start of operation, Immediately, 6 and 24 hours after the completion of the operation. Method of measurement: Blood test. Mean arterial pressure. Timepoint: Before anesthesia induction (Before intervention), after intubation, every 15 minutes until the end of the recovery period. Method of measurement: Gauge pressure. Heart rate. Timepoint: Before anesthesia induction (Before intervention), after intubation, every 15 minutes until the end of the recovery period. Method of measurement: Electrocardiograph. Ahvaz University of Medical Sciences Approved 2018-04-21 Ethics committee of Ahvaz University of Medical Sciences Golestan Blv., Research deputy, Ahvaz Jundishapur University Of Medical Sciences Ahvaz Khouzestan Iran (Islamic Republic of)