IRCT20110514006480N14 IRCT 2018-06-08 Shahre-kord University of Medical Sciences Effect of Topical 1% Hedera helix L. Extract gel in Treatment of Primary Knee Osteoarthritis Comparing the effect of Topical 1% Hedera helix L. Extract gel and 1% Diclofenac gel in the Treatment of Primary Knee Osteoarthritis Patients 2018-06-05 anticipated 150 Complete https://irct.ir/trial/31274 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients will be divided into three groups by simple random sampling and Using three categories of cards that listed on them the letters A, B and C, Blinding description: In this study considering the use of similar tubes in all three groups participants and their carers, as well as the assessor, are not aware of the contents of the tubes. 3 Knee Osteoarthritis. Intervention 1: Intervention group 1: topical use of 1% diclofenac gel (the tubes of 60 gram); three times a day for six weeks and each time applied the gel over the site of interest for 3 to 5 minutes. Intervention 2: Intervention group 2: topical use of 1% H. helix extract 1% gel (the tubes of 60 gram); three times a day for six weeks and each time applied the gel over the site of interest for 3 to 5 minutes. Intervention 3: Control group: topical use of placebo (the tubes of 60 gram); three times a day for six weeks and each time applied the gel over the site of interest for 3 to 5 minutes. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information.