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IRCT20180521039766N1 IRCT 2018-06-25 Artesh University of Medical Sciences Intracanal Medicaments and Root Canal Treatment Pain Study of the Efficacy of Intracanal Medicaments on Tooth Root Canal Treatment Pain Management 2018-06-22 anticipated 90 Complete https://irct.ir/trial/31380 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: patient will be select by random number table, Blinding description: Patient, dentist and statistical analyzer will be blinded and drugs will be prepared and given to the dentist by the dental assistant. 3 inter appointments pain after cleaning and shaping of root canal. Intervention 1: Intervention group: treated by mixture of calcium hydroxide and %0/9 normal saline. Intervention 2: Intervention group: treated by mixture of calcium hydroxide and %2 Chlorhexidine. Intervention 3: Intervention group: treated by mixture of calcium hydroxide and dexamethasone (8mg/2cc). https://doi.org/10.22037/iej.v14i1.22815 Abstract Introduction: After treating the tooth root canal, pain is one of the problems that many patients are facing. In order to reduce pain, and regarding the advice of treating necrotic teeth during several sessions, intra-canal medicaments can be used between sessions. The purpose of this study is to compare pain relieving effect of calcium hydroxide combined with three solutions of normal saline, chlorhexidine 2% and dexamethasone. Materials and methods: This triple blind randomized clinical trial was performed on 90 necrotic molars and premolars. The patients were classified in three medicaments' groups including mixture of calcium hydroxide and normal saline (G1), chlorhexidine 2% (G2) or dexamethasone (G3) that were placed in the canal during the first treatment session. The patients were provided with a Heft-Parker Visual Analog Scale form to record their pain in different intervals of 4, 24, 48, 72 and 96 h after cleaning and shaping the root canal. Data analysis was carried out using the Chi-Square, one-way ANOVA and Repeated Measure tests. Results: No significant difference was observed in the mean pain of the groups after 4 h (P>0.05). However, a significant difference was found between G1 and G3 in the mean pain from day 1 to 72 h after treatment. The mean pain was less in dexamethasone (G3) group (P<0.05), but the difference was not statistically significant at 96 h after treatment (P>0.05). No significant difference was found between "G2-G1" and "G2-G3" groups at different time intervals (P>0.05). Conclusion: The mixture of calcium hydroxide and dexamethasone compared to calcium hydroxide and normal saline in short and medium time had a significant effect on reducing pain after cleaning and shaping the root canal. It seems that the mixture of calcium hydroxide and dexamethasone can be considered as an effective medicament on reducing pain during root canal treatment sessions. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is it is not decided yet, some journals will request statistical files in that case ethical consideration and security of patient identity will be considered.
public Arash Ghanbarzadegan
Etemadzadeh St., West Fatemi St.
Tehran Iran (Islamic Republic of) 1411718541 +98 21 8609 6351 Arash.ghanbarzadegan@yahoo.com Artesh University of Medical Sciences scientific Arash Ghanbarzadegan
Moalem st. aja dental school, endodontics department
Tehran Iran (Islamic Republic of) 1411718541 +98 21 8609 6351 arash.ghanbarzadegan@yahoo.com Artesh University of Medical Sciences Iran (Islamic Republic of) without any systemic diseases molar or premolar tooth with necrotic pulp permanent and closed apex tooth tooth shouldn't have any kind of resorption patient should not use any NSAIDS in last three hours before treatment no limit no limit Both patient won't come for the following treatment appointment patient doesn't prefer to collaborate don't complete the pain in the charts by the patient Treatment - Drugs Treatment - Drugs Treatment - Drugs Intervention group: treated by mixture of calcium hydroxide and %0/9 normal saline. Intervention group: treated by mixture of calcium hydroxide and %2 Chlorhexidine. Intervention group: treated by mixture of calcium hydroxide and dexamethasone (8mg/2cc). Inter appointments pain after cleaning and shaping of tooth root canal. Timepoint: 4 hours after treatment, the first day, the second day, the third day and the fourth day. Method of measurement: Visual Analog Scale. Artesh University of Medical Sciences Approved 2018-06-03 Ethics committee of Aja University of Medical Sciences Etemadzadeh St., West Fatemi St. Tehran Tehran Iran (Islamic Republic of)