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IRCT20180407039213N1 IRCT 2018-06-29 Birjand University of Medical Sciences The effectiveness of licorice solution in Recurrent Aphthous Stomatitis - Comparison of the effectiveness of Glycyrrhiza glabra solution with Diphenhydramine Elixir in the management of pain and duration of Recurrent Aphthous Stomatitis 2018-06-20 anticipated 70 Complete https://irct.ir/trial/31497 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Individual simple randomization by sealed envelope, Blinding description: In this study, participants, major researcher, data collectors were kept blind. N/A Recurrent Aphthous Stomatitis. Intervention 1: Intervention group: Patients with RAS gargle licorice 5% in Diphenhydramine every 6 hours (3 ml for 3 minutes) until improvement. Intervention 2: Control group: RAS patients gargle Diphenhydramine without licorice every 6 hours (3 ml for 3 minutes) until improvement. No - There is not a plan to make this available Justification or reason for not sharing IPD is Because its not mandatory yet
public Akbari Narjes
Ghaffari street
Birjand Iran (Islamic Republic of) ۹۷۱۷۸۵۳۵۷۷ +98 56 3239 5000 narges-akbare4021@yahoo.com Birjand University of Medical Sciences scientific Akbari Narjes
Ghaffari
Birjand Iran (Islamic Republic of) ۹۷۱۷۸۵۳۵۷۷ +98 56 3239 5000 narges-akbare4021@yahoo.com Birjand University of Medical Sciences Iran (Islamic Republic of) Patients with RAS symptoms for less than 1 day 15 years 40 years Both The patients who did not sign the letter of informed consent Patient with hypertension (greater than 80/130) Use of systemic aphthous treatment (over the past three months) and topical treatment during the procedure Atypical aphthous cases and cases suspected of Behcet's syndrome, inflammatory bowel disease. Pregnant or lactating women Patients with Diabetes Patients with RAS symptoms for more than 1 day K12.0 Recurrent oral aphthae Treatment - Drugs Treatment - Drugs Intervention group: Patients with RAS gargle licorice 5% in Diphenhydramine every 6 hours (3 ml for 3 minutes) until improvement Control group: RAS patients gargle Diphenhydramine without licorice every 6 hours (3 ml for 3 minutes) until improvement Improvement of pain and duration of Recurrent Aphthous Stomatitis symptoms. Timepoint: Measurement of pain intensity and healing of wound in second, third, and fifth days of intervention. Method of measurement: Visual Analogue Scale (VAS) to measure pain and physical examination to detect wound healing. Birjand University of Medical Sciences Approved 2018-03-06 Ethics committee of Birjand University of Medical Sciences Dentistry faculty, Birjand University of Medical Sciences, Ghaffari street, Birjand, Iran Birjand South Khorasan Iran (Islamic Republic of)