IRCT20091023002624N26 IRCT 2018-08-03 Iran University of Medical Sciences Treatment of preterm labor A comparative study on the efficacy of nifedipine and indomethacin for prevention of preterm birth as monotherapy and combination therapy 2016-05-01 anticipated 150 Complete https://irct.ir/trial/31694 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: simple individual randomization using sealed envelops, Blinding description: The participants and the investigators did not know how the patients were allocated to the three groups. The groups were named as A, B and C and placebo were used to blind them. 2-3 Condition 1: preterm birth, Preterm delivery, preterm uterine contractions, preterm labor. Condition 2: preterm birth, Preterm delivery, preterm uterine contractions, preterm labor. Condition 3: preterm birth, Preterm delivery, preterm uterine contractions, preterm labor. Intervention 1: Intervention group: group A; 100 mg rectal indomethacin was administered along with an oral placebo. If the patient responded to the initial treatment after two hours, 25 mg of oral indomethacin was administered every 4 hours plus placebo. The maximum daily dosage of indomethacin was 200 mg/day and the maximum duration of administration was 48 hours. Intervention 2: Intervention group: group B; 20 mg oral nifedipine was administered along with a rectal placebo. After 90 minutes, more 20 mg of oral nifedipine was administered. In case of responding to the initial treatment, 20 mg of oral nifedipine was continued every 3 hours for 72 hours at a maximum dose of 180 mg per day, with a placebo that was given every 4 hours (similar to the indomethacin protocol). Intervention 3: Intervention group: group C; a combination of rectal indomethacin and oral nifedipine was administered per protocol as mentioned above. Yes - There is a plan to make this available What will be shared: Presenting at a paper, congress or seminars. When: After publication of the paper To whom: Iran University of Medical Sciences Conditions: Permission from Iran University of Medical Sciences Where to obtain: From Iran University of Medical Sciences How to obtain: Request from Iran University of Medical Sciences. Comments: