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IRCT201701193140N20 IRCT 2017-03-29 Vice Chancellor for Research, Tabriz University of Medical Sciences The effect of Cumin pearl on treatment of metabolic syndrome Effects of Cuminum cyminum L. supplementation on components, inflammatory and oxidative stress indices in patients with metabolic syndrome. 2017-02-19 anticipated 48 Complete https://irct.ir/trial/3186 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive. N/A Metabolic Syndrome. Intervention 1: Intervention group: Cumin essential oil capsule (75 mg), 3 times a day for 8 weeks. Intervention 2: Contol group: Placebo capsule (75mg), 3 times a day for 8 weeks.
public Ashti Morovati
Faculty of Nutrition and food science, Tabriz University of Medical Sciences, Golgasht st, Tabriz
Tabriz Iran (Islamic Republic of) +98 41 3335 5921 ashti.morovati@yahoo.com Faculty of Nutrition and Food Science, Tabriz University of Medical Sceinces scientific Bahram Pourghassem Gargari
Faculty of Nutrition and food science, Tabriz University of Medical Sciences, Golgasht st, Tabriz
Tabriz Iran (Islamic Republic of) +98 41 3336 2117 bahrampg@yahoo.com; pourghassemb@tbzmed.ac.ir Faculty of Nutrition and food sciences, Tabriz University of Medical Sceinces Iran (Islamic Republic of) Inclusion criteria: Willingness to participate; age 18-60 years; affected by metabolic syndrome with three out of five criteria: waist circumference>91 cm in women and >89 cm for men; serum triglyceride≥150 mg/dL; fasting serum glucose≥100mg/dL; serum HDL-C<40 mg/dL in men and <50 mg/dl in women; systolic blood pressure≥130mmhg and/or diastolic blood pressure≥ 85mmhg. Exclusion criteria: pregnancy or lactation; usage of insulin; renal or liver failure; thyroid disorder; following a specific diet; alcohol intake; smoking; being menopause; usage of nutritional supplement in the past 3 month of the study; taking of corticosteroids or immunosuppressive drugs .... 18 years 60 years Both E88.9 metabolic disorders not specified Prevention Placebo Intervention group: Cumin essential oil capsule (75 mg), 3 times a day for 8 weeks Contol group: Placebo capsule (75mg), 3 times a day for 8 weeks Anthropometric idices. Timepoint: Baseline and end of study. Method of measurement: Stadiometer, Scale, Tape. Lipid profile. Timepoint: Baseline and end of study. Method of measurement: Biochemical Analysis. Insulin. Timepoint: Baseline and end of study. Method of measurement: ELISA. Energy intake. Timepoint: Baseline and end of study. Method of measurement: Three day dietary record questionnare. Macronutrient. Timepoint: Baseline and end of study. Method of measurement: Three day dietary record questionnare. Micronutrient. Timepoint: Baseline and end of study. Method of measurement: Three day dietary record questionnare. Hemoglobin A1c. Timepoint: Baseline and end of study. Method of measurement: Spectrophotometry. Fasting Blood Sugar. Timepoint: Baseline and end of study. Method of measurement: Spectrophotometry. Insulin resistance. Timepoint: Baseline and end of study. Method of measurement: Formula. MDA. Timepoint: Baseline and end of study. Method of measurement: Spectrophotometry. Total anti oxidant. Timepoint: Baseline and end of study. Method of measurement: Spectrophotometry. Catalase. Timepoint: Baseline and end of study. Method of measurement: Spectrophotometry. Superoxide dismutase. Timepoint: Baseline and end of study. Method of measurement: Spectrophotometry. High sensitive C-Reactive Protein. Timepoint: Baseline and end of study. Method of measurement: Spectrophotometry. Tumor Necrosis Factor. Timepoint: Baseline and end of study. Method of measurement: ELISA. Systolic and diastolic blood pressure. Timepoint: Baseline and end of study. Method of measurement: Digital monometer. Vice Chancellor for Research, Tabriz University of Medical Sciences Approved 2017-01-23 Ethics committee of Tabriz University of Medical Sciences No 2 Central Building, Tabriz University of Medical Sciences, Golgasht Street, Tabriz Tabriz Iran (Islamic Republic of)