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IRCT20150721023270N2 IRCT 2018-07-12 Qazvin University of Medical Sciences The effect of Dexamethasone and Morphine administration by three methods on pain control after lumbar spinal surgery The comparison effect of Dexamethasone and Morphine administration (intravenous, intrathecal and local) in pain control following lumbar spinal surgery 2017-09-23 anticipated 75 Complete https://irct.ir/trial/31910 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: The patients are divided in three groups (25 cases) by using colorful cards, Blinding description: The patient is not aware of the type of intervention. 3 Lumbar spinal disease. Intervention 1: Intervention group: Group A: Putting a surgi-cell in dura site which impregnated with 2 mg of Morphine and 0.1 mg/kg of Dexamethasone. Intervention 2: Intervention group: Group B: Injection of 0.02 mg/kg Morphine and 0.1 mg/kg Dexamethasone using the interatecal method. Intervention 3: Intervention group: Group C: Injection of 0.1 to 0.2 mg/kg Morphine and 0.1 mg/kg Dexamethasone intravenously before closure of the surgical site. Yes - There is a plan to make this available What will be shared: - When: - To whom: - Conditions: - Where to obtain: - How to obtain: - Comments:
public Bahareh Behnam Ghader
Padegan street, Qazvin
Qazvin Iran (Islamic Republic of) 34139-96134 +98 28 3333 5800 b.behnamghader6@gmail.com Qazvin University of Medical Sciences scientific Dr.Seyed Mohsen Hasani Barzi
Padegan street, Qazvin
Qazvin Iran (Islamic Republic of) 34139-96134 +98 28 3333 5800 smbarzi@qums.ac.ir Qazvin University of Medical Sciences Iran (Islamic Republic of) Patients candidates for discectomy, laminectomy and fusion in more than one segment. no limit no limit Both Trauma patients, tumor of the lumbar region, rheumatologic and metabolic diseases, cardiovascular disease Drug sensitivity to Morphine Addiction history Non-completion of conservative treatment Previous lumbar spine surgery BMI index at least 35 Surgical complications such as surgical site infection Hematoma, and drug side effects such as apnea S34.10 Unspecified injury to lumbar spinal cord Treatment - Drugs Treatment - Other Treatment - Drugs Intervention group: Group A: Putting a surgi-cell in dura site which impregnated with 2 mg of Morphine and 0.1 mg/kg of Dexamethasone Intervention group: Group B: Injection of 0.02 mg/kg Morphine and 0.1 mg/kg Dexamethasone using the interatecal method Intervention group: Group C: Injection of 0.1 to 0.2 mg/kg Morphine and 0.1 mg/kg Dexamethasone intravenously before closure of the surgical site Pain. Timepoint: At 6، 12، 24، and 48 hours after surgery. Method of measurement: Visual analogues scale. Vomiting and nausea. Timepoint: At 6، 12، 24 and 48 hours after surgery. Method of measurement: Observation. Total amount of Morphine requirement. Timepoint: At 6، 12، 24 and 48 hours after surgery. Method of measurement: Interview with patient. Qazvin University of Medical Sciences Approved 2016-11-26 Ethical committee of Qazvin University of Medical Sciences Shahid Bahonar Blvd., Qazvin Qazvin Qazvin Iran (Islamic Republic of)