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IRCT20171203037724N1 IRCT 2018-10-13 Rasht University of Medical Sciences Investigating apple vinegar effects on blood pressure in healthy subjects Investigating the short-term effects of apple vinegar consumption on systolic and diastolic blood pressure, pulse pressure and heart rate in healthy subjects 2018-10-22 anticipated 40 Complete https://irct.ir/trial/32052 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: Randomization method and description: Randomization method is based on gradual referrals and having inclusion criteria and interest in participating in the study. Randomization unit: individual Randomization layers: gender Randomization Tool: Random Allocation Software The method of creating a random sequence: Sequence Allocation concealment: Selection sequence of samples is divided into four groups of women (20) and men (20) that are kept in sealed letters at the Cardiovascular Diseases Research Center of Heshmat Hospital at Rasht and are opened at the beginning of the study each morning and closed at night from outset of the study. Based on the sex of the samples and having the criteria for entering the sequencing, the samples are placed in one of the four groups (low dose - moderate dose- high dose and control). 2 Blood pressure. Intervention 1: The intervention group 1 will receive single dose of 22 grams of 5% traditional apple vinegar whose volume is raised to 200 cc by adding water. Intervention 2: The intervention group 2 will receive single dose of 28 grams of 5% traditional apple vinegar whose volume is raised to 200 cc by adding water. Intervention 3: The intervention group 3 will receive single dose of 32 grams of 5% traditional apple vinegar whose volume is raised to 200 cc by adding water. Intervention 4: The control group will receive single dose of 200 cc of mineral water. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information.
public Shirin Parvinroo
School of Pharmacy, Guilan University of Medical Sciences Campus, Fouman – Saravan Road
Rasht Iran (Islamic Republic of) 4194173774 +98 13 3348 6470 shirin.parvinroo@gums.ac.ir Rasht University of Medical Sciences scientific Shirin Parvinroo
School of Pharmacy, Guilan University of Medical Sciences Campus, Fouman - Saravan Road
Rasht Iran (Islamic Republic of) 4194173774 +98 13 3348 6470 shirin.parvinroo@gums.ac.ir Rasht University of Medical Sciences Iran (Islamic Republic of) 20 to 60 years healthy people No history of allergy to vinegar No digestive problems such as reflux and stomach problems No smoking a body mass index between 18.5 to 29.9 Kg/m2 20 years 60 years Both Unwillingness of individuals to cooperate with the study procedure I10 Essential (primary) hypertension Prevention Prevention Prevention Prevention The intervention group 1 will receive single dose of 22 grams of 5% traditional apple vinegar whose volume is raised to 200 cc by adding water. The intervention group 2 will receive single dose of 28 grams of 5% traditional apple vinegar whose volume is raised to 200 cc by adding water. The intervention group 3 will receive single dose of 32 grams of 5% traditional apple vinegar whose volume is raised to 200 cc by adding water. The control group will receive single dose of 200 cc of mineral water. Reduction of systolic and diastolic blood pressure. Timepoint: ُSystolic and diastolic blood pressure will be measured before intervention and with 15-minute intervals after intervention up to 120 minutes. Method of measurement: Systolic and diastolic blood pressure will be measured by a digital sphygmomanometer. Pulse pressure. Timepoint: Before intervention and with 15-minute intervals after intervention up to 120 minutes. Method of measurement: Difference of systolic and diastolic blood pressure. Heart rate. Timepoint: Before intervention and end of intervention. Method of measurement: Electrocardiogram. Rasht University of Medical Sciences Approved 2018-06-11 Ethics committee of Guilan University of Medical Sciences Deputy of Research and Technology of Guilan University of Medical Sciences, opposite 17th Shahrivar Hospital, Shahid Siadati St., Namjoo Blv. Rasht Guilan Iran (Islamic Republic of)