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IRCT138811063182N1 IRCT 2010-06-06 Vice Chancellor for Research, Mashhad University of Medical Sciences The efficacy of Rosa damascena extract in the treatment of recurrent aphthous stomatitis The efficacy of Rosa damascena extract in the treatment of recurrent aphthous stomatitis: A randomized parallel controlled trial 2008-02-10 anticipated 42 Complete https://irct.ir/trial/3223 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 2 Recurrent aphthous stomatitis. Intervention 1: Placebo. Intervention 2: Rosa damascena extract 20%, 4 times per day.
public Keyvan Sohrabi
School of Dentistry
Mashhad Iran (Islamic Republic of) 91735 +98 51 1882 9501 k1sohrabi@gmail.com Mashahd University of Medical Sciences scientific Dr H.Hoseinpour
School of dentistry, Departement of oral medicine
Mashhad Iran (Islamic Republic of) 91735 +98 51 1882 9501 HoseinpourH@mums.ac.ir Mashhad university of medical sciences Iran (Islamic Republic of) Inclusion criteria: The presence of at least one aphthous ulcer measuring no more than 10 mm in diameter (formation no more than 48h), had no underlying systemic or immunologic disease such as rheumatoid arthritis and behcet syndrome. Patients were excluded if they had used NSAIDs, corticosteroids or other immunoregulatory agents within 1 month prior to the study or were less than 18 years of age. 18 years 70 years Both K12.0 Recurrent oral aphthae Placebo Treatment - Drugs Placebo Rosa damascena extract 20%, 4 times per day Change in Ulcer Size (mm2). Timepoint: on day 0 (baseline), days 4, 7, 11 and 14. Method of measurement: Ulcer size is measured by one examiner with the use of a calibrated dental probe with millimeter markings. Change in number of Apthae. Timepoint: on day 0 (baseline), days 4, 7, 11 and 14. Method of measurement: Only ulcers which would come into contact with the rinse (i.e. in the oral cavity) will be considered. Change in Pain. Timepoint: on day 0 (baseline), days 4, 7, 11 and 14. Method of measurement: the Perceived Pain Rating Scale as introduced by Barker et al, 1991. Vice Chancellor for Research, Mashhad University of Medical Sciences Approved 2008-12-30 Mashhad University of Medical Sciences Mashhad University of Medical Sciences Mashhad Iran (Islamic Republic of)