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IRCT20180630040291N1 IRCT 2019-09-09 Iran University of Medical Sciences The effect of rTMS on Amphetamine craving Investigating the effect of rTMS on amphetamine craving in patients with amphethamine dependency 2018-06-22 anticipated 30 Complete https://irct.ir/trial/32327 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Restricted randomization based on random allocation rule, Blinding description: Using sham coil. N/A Amphethamine craving. Intervention 1: Intervention group: The patients will be selected among clients referring to the addiction clinic (MMT) of Tehran Psychiatric Hospital and Tehran Behavioral Sciences Institute, and Iran's Psychiatric Center using convenient sampling method. The research inclusion criteria included 1- People aged 18 to 60 years who have the amphetamines dependence criteria based on DSM-V before the treatment and have undergone treatment and have not used amphetamine at least for 2 weeks 2- The patient report the methamphetamine craving. Exclusion criteria included: Current psychosis, Other substance dependency except for nicotine and caffeine, Contraindication of rTMS, Recent change of medication in past two weeks. Intervention 2: Intervention group: The patients will be selected among clients referring to the addiction clinic (MMT) of Tehran Psychiatric Hospital and Tehran Behavioral Sciences Institute, and Iran's Psychiatric Center using convenient sampling method. The research inclusion criteria included 1- People aged 18 to 60 years who have the amphetamines dependence criteria based on DSM-V before the treatment and have undergone treatment and have not used amphetamine at least for 2 weeks 2- The patient report the methamphetamine craving.Exclusion criteria included: Current psychosis, Other substance dependency except for nicotine and caffeine, Contraindication of rTMS, Recent change of medication in past two weeks. Intervention 3: Control group: The patients will be selected among clients referring to the addiction clinic (MMT) of Tehran Psychiatric Hospital and Tehran Behavioral Sciences Institute, and Iran's Psychiatric Center using convenient sampling method. The research inclusion criteria included 1- People aged 18 to 60 years who have the amphetamines dependence criteria based on DSM-V before the treatment and have undergone treatment and have not used amphetamine at least for 2 weeks 2- The patient report the methamphetamine craving. Exclusion criteria included: Current psychosis, Other substance dependency except for nicotine and caffeine, Contraindication of rTMS, Recent change of medication in past two weeks. Yes - There is a plan to make this available What will be shared: Original article When: At the end of the project To whom: The readers of the journal in which the article will be accepted Conditions: Guideline of the journal Where to obtain: It is not determined yet How to obtain: Guideline of the journal Comments:
public Atefeh Ghanbari Jolfaei
Rasoul akram hospital, Niayesh St.
Tehran Iran (Islamic Republic of) 1449614535 +98 21 6651 9519 draghj@yahoo.com Iran University of Medical Sciences scientific Atefeh Ghanbari Jolfaei
Rasoul akram hospital, Niayesh St.
Tehran Iran (Islamic Republic of) 1445613131 +98 21 6651 9519 draghj@yahoo.com Iran University of Medical Sciences Iran (Islamic Republic of) Being right handed, Having DSM-IV criteria of amphethamine dependency, At least two weeks of amphethamine withdrawal; Having amphethamine craving 18 years 60 years Both Current psychosis, Other substance dependency except for nicotine and caffeine, Contraindication of rTMS, Recent change of medication in past two weeks F19.1 Other psychoactive substance abuse Treatment - Devices Treatment - Devices Other Intervention group: The patients will be selected among clients referring to the addiction clinic (MMT) of Tehran Psychiatric Hospital and Tehran Behavioral Sciences Institute, and Iran's Psychiatric Center using convenient sampling method. The research inclusion criteria included 1- People aged 18 to 60 years who have the amphetamines dependence criteria based on DSM-V before the treatment and have undergone treatment and have not used amphetamine at least for 2 weeks 2- The patient report the methamphetamine craving. Exclusion criteria included: Current psychosis, Other substance dependency except for nicotine and caffeine, Contraindication of rTMS, Recent change of medication in past two weeks Intervention group: The patients will be selected among clients referring to the addiction clinic (MMT) of Tehran Psychiatric Hospital and Tehran Behavioral Sciences Institute, and Iran's Psychiatric Center using convenient sampling method. The research inclusion criteria included 1- People aged 18 to 60 years who have the amphetamines dependence criteria based on DSM-V before the treatment and have undergone treatment and have not used amphetamine at least for 2 weeks 2- The patient report the methamphetamine craving.Exclusion criteria included: Current psychosis, Other substance dependency except for nicotine and caffeine, Contraindication of rTMS, Recent change of medication in past two weeks Control group: The patients will be selected among clients referring to the addiction clinic (MMT) of Tehran Psychiatric Hospital and Tehran Behavioral Sciences Institute, and Iran's Psychiatric Center using convenient sampling method. The research inclusion criteria included 1- People aged 18 to 60 years who have the amphetamines dependence criteria based on DSM-V before the treatment and have undergone treatment and have not used amphetamine at least for 2 weeks 2- The patient report the methamphetamine craving. Exclusion criteria included: Current psychosis, Other substance dependency except for nicotine and caffeine, Contraindication of rTMS, Recent change of medication in past two weeks Amphetamine craving. Timepoint: Before rTMS and at least 1 week after the end of rTMS. Method of measurement: VAS Visual cue_indused craving assessment. Number of hospitalizations. Timepoint: Six months after rTMS. Method of measurement: Counting. Iran University of Medical Sciences Approved 2018-01-15 Iran University of Medical Sciencs Hemmat highway Tehran Tehran Iran (Islamic Republic of)