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IRCT20180618040131N1 IRCT 2018-08-13 Islamic Azad University The effect Allicin and Silybum Marianum on suindicators of muscle damage CPK,LDH,AST,ALT Comparison of the effect a period of consumption Allicin and Silybum Marianum supplementation with four weeks wrestling selective training on some of the indicators of muscle damage in trained wrestlers 2018-07-23 anticipated 33 Complete https://irct.ir/trial/32401 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: First, it is purposeful and selective and then randomly The methodology will be such that one of the members of the research team (other than the researcher and participants) will be present at the Qom Clubs and will provide names, records, and contact details of all athletes who are active. Then, from among these people, those who have 5 years of history of the wrestling and at least one title at the provincial level competitions will be selected and they will be invited by telephone to attend the club. The wrestlers will be assigned a number if they have criteria for entering the study and have a willingness to participate in the study. Then, by a research member (other than the researcher and participants), using the Random allocation rule, a set of numbers to Group A will be assigned to a group B and a set to the C group.The goal is to prevent any anticipation of future allocations from participants and researchers. For example, in this study with a sample size of 33 people, the balls that has the same weight and shape (33 numbers) are drawn into a container, and each of the letters A, B, C has 11 balls (three groups of letters) placed in the other container. Then, randomly, from each container, a number and a letter are left out of the container without replacement, and the resulting sequence is recorded. Akarca et al. Used this method in their random assignment, Blinding description: Prior to the commencement of the study, supplementary canisters and placebo can be marked by a person other than the researcher so that the knowledge of the researcher and the learners about the type of capsules received is not taken into consideration. The supplement and placebo will be administered under the supervision of the same person (he is a doctor). Which also monitors the subjects. 4 Serum markers of muscle injury. Intervention 1: Intervention group: first, 24 hours after blood sampling, the subjects received 3 tablets 300 mg containing 1/1 mg of allicin for one month each day made in Isfahan Pharmaceutical Company. Pills will be put in powder form in the capsule. Intervention 2: Intervention group: second, 24 hours after blood sampling, the subjects received 3 tablets containing 140 mg of silybium maryanum for one month each day made in Isfahan Pharmaceutical Company. Pills will be put in powder form in the capsule. Intervention 3: Control group:Third, 24 hours after blood sampling, the subjects received 3 tablets containing Starch. Pills will be put in powder form in the capsule. Yes - There is a plan to make this available What will be shared: Comparison of the effect a period of consumption Allicin and Silybum Marianum supplementation with four weeks wrestling selective training on some of the indicators of muscle damage in trained wrestlers. Due to limited and controversial studies, the possible synergistic effect of these two antioxidants and the lack of access to the studied on the effects of silymarin and allicin supplementation and sporting activity necessitate that the effect of Allicin and Silybum Marianum supplementation on some of the serum indicators of injury Muscle (Phosphocreatine kinase-lactate dehydrogenase-alanine Aminotransferase- Aspartate aminotransferase) after one month, selected exercises are carried out in male wrestlers who have been practicing. so that coaches and sports technicians can relate to the results prevent to some extent the occurrence of undesirable signs and symptoms and the cost of double treatment costs. When: Next 3 months To whom: By giving the resources to all people is allowed. Conditions: By giving the resources Where to obtain: Email researcher m-sharifian@iau-arak.ac.ir How to obtain: Email researcher m-sharifian@iau-arak.ac.ir Comments: Doctor will also monitor this study, and capsules, supplements will be provided from the pharmacy.
public Mehdi Sharifian
Arak- Imam Komeini squar - Imam Komeini Boulevard – Amir kabir university - Islamic Azad University of Arak
Arak Iran (Islamic Republic of) 9131138361 +98 86 3341 2314 m-sharifian@iau-arak.ac.ir Islamic Azad University scientific Mehdi Sharifian
Nader Mojtamae , 5 Golestan Ave.,Yadegar emam street., Arak Town
Arak Iran (Islamic Republic of) 9131138361 +98 86 3465 5233 m-sharifian@iau-arak.ac.ir Islamic Azad University Iran (Islamic Republic of) Wrestlers who have had a continuous training record of at least five years. At least one championship title has been gained at the provincial level. 15 years 20 years Male Use of anti-inflammatory drugs and vitamin supplements Disorders that increase with supplementation of garlic (such as platelet problems, gastritis, hypotension, inflammation of the oral mucosa) Prevention Prevention Placebo Intervention group: first, 24 hours after blood sampling, the subjects received 3 tablets 300 mg containing 1/1 mg of allicin for one month each day made in Isfahan Pharmaceutical Company. Pills will be put in powder form in the capsule. Intervention group: second, 24 hours after blood sampling, the subjects received 3 tablets containing 140 mg of silybium maryanum for one month each day made in Isfahan Pharmaceutical Company. Pills will be put in powder form in the capsule. Control group:Third, 24 hours after blood sampling, the subjects received 3 tablets containing Starch. Pills will be put in powder form in the capsule Compare differences in the values of CPK change in different groups. Timepoint: At the beginning of the study (before the intervention) and one month after taking supplements and exercise ( one hour after training, 24 hours (fasting) and 36 (fasting). Method of measurement: Autoanalyzer selectra l made in poland, centrifuge(hermel z310- germany), The kits and chemicals required will also be supplied by Iran's Pars Test Company. Compare differences in the values of LDH change in different groups. Timepoint: At the beginning of the study (before the intervention) and one month after taking supplements and exercise ( one hour after training, 24 hours (fasting) and 36 (fasting). Method of measurement: Autoanalyzer selectra l made in poland, centrifuge(hermel z310- germany), The kits and chemicals required will also be supplied by Iran's Pars Test Company. Compare differences in the values of AST change in different groups. Timepoint: At the beginning of the study (before the intervention) and one month after taking supplements and exercise ( one hour after training, 24 hours (fasting) and 36 (fasting). Method of measurement: Autoanalyzer selectra l made in poland, centrifuge(hermel z310- germany), The kits and chemicals required will also be supplied by Iran's Pars Test Company. Compare differences in the values of ALT change in different groups. Timepoint: At the beginning of the study (before the intervention) and one month after taking supplements and exercise ( one hour after training, 24 hours (fasting) and 36 (fasting). Method of measurement: Autoanalyzer selectra l made in poland, centrifuge(hermel z310- germany), The kits and chemicals required will also be supplied by Iran's Pars Test Company. Score Muscle soreness. Timepoint: Measurement of muscular sorness At the beginning of the study (before the intervention) and one month after taking supplements and exercise ( one hour after training, 24 hours (fasting) and 36 (fasting).supplementation of allicin and silibium marianum. Method of measurement: Borg Pain Questionnaire. Islamic Azad University Approved 2018-06-08 Institutional Research Ethics Committee Islamic Azad University Boroujerd-Branch Navab Square, Imam Khomeini Complex (Imam Khomeini), Borujerd Town Borujerd Lorestan Iran (Islamic Republic of)