IRCT20151109024975N9 IRCT 2018-08-01 Mazandaran University of Medical Sciences Effect of Zinc in improvement of Aphthous RAS Evaluation of the effectiveness of Zinc Sulfate mucoadhesive tablet in the improvement of Recurrent Aphthous Stomatitis (RAS) 2018-01-21 anticipated 46 Complete https://irct.ir/trial/32423 interventional Randomization: Not randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Blinding description: The examiner is unaware of the contents of the boxes of drugs and they are quite similar. 2-3 Recurrent Aphthous Stomoatitis. Intervention 1: Intervention group: Patients received mucoadhesive tablets three times a day containing Zinc Sulfate (morning, afternoon and night). How to use the mucoadhesive tablets was taught to patients so that they should avoid eating and drinking for 30 minutes after applying the tablet. The chemical composition of the Zinc Sulfate mucoadhesive tablets tablet: A certain amount of Zinc Sulfate 8H20 (containing 5 mg of Zinc) was selected as a therapeutic dose to evaluate the effects of this substance on the improvement of oral Aphthous. Other components include Carbopol 940 and Sodium Alginate as a tablet binding agent to the mucus, starch as a filler to the body of the tablet, and sucrose to create the proper taste and help the pill to open gradually in the mouth. Intervention 2: Control group: Patients received mucoadhesive tablets three times a day containing Placebo (morning, afternoon and night). How to use the mucoadhesive tablets was taught to patients so that they should avoid eating and drinking for 30 minutes after applying the tablet. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information