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IRCT20180715040479N1 IRCT 2018-10-02 Tehran University of Medical Sciences The assesment of the effect of low calorie with moderate fiber diet on Brain-derived neurotrophic factor(BDNF) serum levels in obese and overweight type2 diabetic patients with different APO AII- 265T/C polymorphism The assesment of the effect of low calorie with moderate fiber diet on Brain-derived neurotrophic factor(BDNF) serum levels in obese and overweight type2 diabetic patients with different APO AII- 265T/C polymorphism 2018-08-06 anticipated 56 Complete https://irct.ir/trial/32547 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Prevention. N/A Type 2 diabetes. Intervention group: This study will be performed on 56 diabetic patients. Patients will have a low-energy and fiber-rich diet (30 g / day) containing 55-65% carbohydrates, 20-25% fat and 15-20% % Protein will be received. After calculating the amount of energy required, the dietary regimen is adjusted daily for each individual. A total of 21 menu items are set with specific energy, and in each week, 7 calorie-like diets are given to people who have the power to select the desired menu and even repeat it per week. Also, the share of energy in each and every one is the same, which allows people to choose between their meals, such as breakfast, their favorite menu. At the beginning and at the end of the study (after intervention), blood samples are collected from patients, thus collecting 15-20 ml of blood.. Yes - There is a plan to make this available What will be shared: All laboratory data of individuals including blood factors, glucose and fat and other measurable factors in the study will be shared. When: Access to data will be possible for the second half of 1398 To whom: Researchers working in academic and academic institutions Conditions: Statistical analysis related to Trail's studies Use this data solely to conduct a new research Use data to write systematic review articles and meta-analyzes Where to obtain: Dr Fariba koohdani- fkoohdan@tums.ac.ir Dr Maasumeh moradi 00989128390869 How to obtain: All results and documentation will be available up to 1 year after the completion of sampling Comments:
public Fariba koohdani
School of nutrition and dietetics, Hojjadoust S, Naderi Ave, Keshavarz Blvd
Tehran Iran (Islamic Republic of) 1416643931 +98 21 8898 6908 fkoohdan@tums.ac.ir Tehran University of Medical Sciences scientific Ali Nazary
School of Nutrition and Dietetics, Hojjatdoust S, Naderi Ave, Keshavarz Blvd
Tehran Iran (Islamic Republic of) 1416643931 +98 21 8898 6908 a-nazary@razi.tums.ac.ir Tehran University of Medical Sciences Iran (Islamic Republic of) age range 45 to 65 years BMI over the 27 Patients with type 2 diabetes who do not inject insulin 45 years 65 years Both Consumption drugs,tobacco,alcohol Heart disease, stroke, liver disease, kidney failure, thyroid disease, cancer, chronic inflammatory diseases consuption anti-inflammatory drugs and multi-vitamin minerals participate in other interventions Pregnancy and lactation E11 Type 2 diabetes mellitus Prevention Intervention group: This study will be performed on 56 diabetic patients. Patients will have a low-energy and fiber-rich diet (30 g / day) containing 55-65% carbohydrates, 20-25% fat and 15-20% % Protein will be received. After calculating the amount of energy required, the dietary regimen is adjusted daily for each individual. A total of 21 menu items are set with specific energy, and in each week, 7 calorie-like diets are given to people who have the power to select the desired menu and even repeat it per week. Also, the share of energy in each and every one is the same, which allows people to choose between their meals, such as breakfast, their favorite menu. At the beginning and at the end of the study (after intervention), blood samples are collected from patients, thus collecting 15-20 ml of blood. Brain-derived neurotrophic factor (BDNF). Timepoint: The beginning of the study (before the intervention) and the end of the study (after the intervention). Method of measurement: Elisa kit. Obesity and Overweight. Timepoint: The beginning of the study (before the intervention) and the end of the study (after intervention). Method of measurement: Scales. Tehran University of Medical Sciences Approved 2018-06-28 Ethics Committee of Tehran University of Medical Sciences Qods Ave, Keshavarz Blvd Tehran Tehran Iran (Islamic Republic of)