IRCT20100127003210N15 IRCT 2018-06-25 Shahid Beheshti University of Medical Sciences Evaluation of Duloxetine effect on Oxaliplatin induced peripheral neuropathy prophylaxis Evaluation of Duloxetine effect on Oxaliplatin induced peripheral neuropathy prophylaxis 2017-02-19 anticipated 40 Complete https://irct.ir/trial/3256 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: In covariate adaptive randomization, a new participant is sequentially assigned to a particular treatment group by taking into account the specific covariates and previous assignments of participants. in this study covariants factors include : 1.sex 2.age 3.cancer stage. we used Graphpad prism for randomization. 3 colorectal cancer. Intervention 1: Intervention group: patient who take duloxetine 30mg/d for first week and then 30 mg BD to 12 weeks. Intervention 2: Control group: Patients in this group receive one placebo capsule during the first week and then take 2 placebo capsules until 12th week of study. No - There is not a plan to make this available Justification or reason for not sharing IPD is Information are confidential