IRCT20180623040199N1 IRCT 2018-08-05 Kerman University of Medical Sciences Effectiveness of wet cupping on moderate and severe acne in patients under treatment with Azithromycin Effectiveness of wet cupping on moderate and severe acne in patients under treatment with Azithromycin 2018-08-06 anticipated 108 Complete https://irct.ir/trial/32654 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: At first, according to the inclusion criteria, patients are selected and then according to the random sequence obtained through the "Blocked Randomization List" (random blocking with 6 blocks), in the same random order, patients will be divided into intervention and control groups, Blinding description: A dermatologist who checks patients at intervals is unaware of the wet cupping. The analyzer is unaware of the patients whom wet cupping is done for them. N/A Acne. Intervention 1: Intervention group: In the back area between the first to third thoracic vertebra, during the first visit and the sixth week, the cupping will be done. In addition, antibiotic antibiotic azithromycin will be given 3 times a week. Intervention 2: Control group:They will receive antibiotic azithromycin three times a week, as well as sham cupping. Yes - There is a plan to make this available What will be shared: It is published through the supplementary file When: 6 months To whom: Researchers and other people can access data if they need it Conditions: For using in systematic review articles, reprogramming and modeling can be used in other studies. In case of need, should be emailed to the programmer or entered university site. Where to obtain: Executor of plan or University How to obtain: Email the scheduler,she answers. Comments: All information is available to others for the advancement of science.