IRCT20110514006480N16 IRCT 2018-08-01 Shahre-kord University of Medical Sciences Effects of oral duloxetine on reduction of symptoms of peripheral neuropathy Comparison of the therapeutic effects of oral duloxetine alone and with combination gel on reduction of symptoms of chemotherapy-induced peripheral neuropathy 2018-08-01 anticipated 90 Complete https://irct.ir/trial/32764 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients will be divided into three groups by simple random sampling and Using three categories of cards that listed on them the letters A, B and C, Blinding description: In this study considering the use of similar drug forms in all three groups participants, researcher, as well as the assessor, are not aware of the type of drug used. 3 Chemotherapy-induced peripheral neuropathy. Intervention 1: Intervention group 1: Patients will receive oral duloxetine 30 mg once daily (in the morning) along with topical placebo gel 1.3 g twice (morning and night) a day. Intervention 2: Intervention group 2: Patients will receive oral duloxetine 30 mg once daily (morning) along with topical combination gel (10 mg of baclofen, 40 mg of amitriptyline, and 20 mg of ketamine) twice daily (morning and night) 1.3 g. Intervention 3: Control group: Patients will receive placebo gel twice a day (morning and night) 1.3 g. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information.