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IRCT20180722040557N1 IRCT 2018-08-07 Esfahan University of Medical Sciences Effect of gabapentin, pregabalin and oral celecoxib on controlling of postoprative pain in orthopaedic lower extremities surgrey Comparison of the prophylactic effects of gabapentin, pregabalin and oral celecoxib and placebo on controlling of postoperative pain in orthopaedic lower extremities surgery with spinal anesthesia 2018-08-11 anticipated 120 Complete https://irct.ir/trial/32795 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: The patients were randomly assigned into four groups of 30, the first, second, third and fourth patients were divided into four groups, and the subsequent patients were randomly distributed in groups so that the sample size Enough in all four groups, Blinding description: In the current double-blinded study, the patients were unaware of their groups and the physician who did not participate in the process of data collection put all the drugs in the same capsules with different codes.The physician who prescribed the drugs was unaware of drug content of each capsule as well. 3 Postoperative pain of lower limb following orthopaedic lower limb surgery. Intervention 1: Intervention group: One hour prior to spinal anesthesia group 1 received 300 mg gabapentin,. Intervention 2: Intervention group: One hour prior to spinal anesthesia group 2 received 75 mg pregabalin. Intervention 3: Intervention group: One hour prior to spinal anesthesia group 3 received 200 mg celecoxib. Intervention 4: Control group: One hour prior to spinal anesthesia control group recieved placebo. No - There is not a plan to make this available Justification or reason for not sharing IPD is No more information
public Marzie Taghvaie
No 17, 6 Ave, Esteghlal Blvd, Shahreza Town
Shahreza Iran (Islamic Republic of) 8618676781 +98 31 5321 5240 dr.taghvaie@gmail.com Esfahan University of Medical Sciences scientific Mohamdreza Safavi
Alzahra Hospital ,Shohadaye Soffe Blvd, Isfahan City
Isfahan Iran (Islamic Republic of) 8174675731 +98 31 3620 2020 safavi@med.mui.ac.ir Esfahan University of Medical Sciences Iran (Islamic Republic of) Candidacy of elective lower limb orthopaedic surgery No contraindication for spinal anesthesia No restriction for sitting position Patient's tendency to spinal anesthesia No risk of increasing intra cranial pressure No suffering from uncontrolled diseases No coagulation disorders 18 years 75 years Both Patient's dissatisfaction to keep on coopration Failling of spinal anesthesia (it was tried twice maximally) M79.6 Pain in limb, hand, foot, fingers and toes Treatment - Drugs Treatment - Drugs Treatment - Drugs Placebo Intervention group: One hour prior to spinal anesthesia group 1 received 300 mg gabapentin, Intervention group: One hour prior to spinal anesthesia group 2 received 75 mg pregabalin Intervention group: One hour prior to spinal anesthesia group 3 received 200 mg celecoxib Control group: One hour prior to spinal anesthesia control group recieved placebo Post orthopedic sergical pain of the lower extremities. Timepoint: Each 60 minutes for 2 times and each 6 hours for the next 4 times. Method of measurement: Visual analog scale. Esfahan University of Medical Sciences Approved 2017-05-31 Ethics committee of Esfahan University of Medical Science Hezar Jerib Avenue, Isfahan , Iran Isfahan Isfehan Iran (Islamic Republic of)