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IRCT20180404039187N2 IRCT 2018-11-23 Tabriz University of Medical Sciences study the effects of allopurinol in patients with non-alcoholic fatty liver disease study the effects of Allopurinol on liver enzymes and grade of fatty liver on ultrasound in patients with non-alcoholic fatty liver disease 2017-01-23 anticipated 100 Complete https://irct.ir/trial/32805 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Arrange the accident stages: 1) Determine the volume of each block (Foursquare blocks) 2) Prepare block lists and assign numbers to them AABB(1) ABAB(2) ABBA(3) BBAA(4) BABA(5) BAAB(6) 3) Selection of random numbers between 1 and 6 4) Identification of the Treatment Assignment For example: AABB(1)_BBAA(4)_ABAB(2)_BABA(5), Blinding description: Double blind: People in the study (participants) and observers (researchers) who include researchers, clinical caregivers and physicians, assess and analyze data, and other care and treatment personnel do not know who and in which group they are during the study. 3 non-alcoholic fatty liver disease. Intervention 1: Intervention group: consumption of 100 mg Allopurinol daily for 6 months. Intervention 2: Control group: routin care. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information
public Dr Elnaz Shaseb
Pharmacy faculty of tabriz Medical University, Golgaste St, Azadi Avenue, Tabriz
Tabriz Iran (Islamic Republic of) 5166614766 +98 41 3334 1449 elnaz_shaseb_64@yahoo.com Tabriz University of Medical Sciences scientific Dr Elnaz Shaseb
Pharmacy faculty of Tabriz Medical University, Golgaste St, Azadi Avenue, Tabriz
Tabriz Iran (Islamic Republic of) 51666414766 +98 41 3334 1449 elnaz_shaseb_64@yahoo.com Tabriz University of Medical Sciences Iran (Islamic Republic of) patients whom have non-alcoholic fatty liver disease based on the ultrasound and laboratory tests patients whom have non-symptomatic hyperuricemia (serum uric acid >7 mg/dl for men and >6.5 mg/dl for women) 18 years 65 years Both pregnancy and lactation allergy to Allopurinol or its contents use of alcohol patients with renal deficiency with creatinine clearance (GFR) <30 mg/ml simultaneous use of drugs which have interaction with Allopurinol (mercaptopurine, azathioprine, ...) patients who have had gout or who are using uricosuric agents or thiazide diuretics K76.0 Fatty (change of) liver, not elsewhere classified Treatment - Drugs Diagnosis Intervention group: consumption of 100 mg Allopurinol daily for 6 months Control group: routin care Serum liver enzymes AST and ALT and grade of fatty liver based on ultrasound. Timepoint: at the beginning and 3 and 6 months later. Method of measurement: laboratory tests and ultrasound. Tabriz University of Medical Sciences Approved 2018-09-25 Ethics Committee of Tabriz University of Medical Sciences Research & Technology Dept, Central Building No. 2, Third Floor, Tabriz University of Medical Sciences, Golghast St, Tabriz Tabriz East Azarbaijan Iran (Islamic Republic of)