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IRCT20180721040545N1 IRCT 2018-08-07 Islamic Azad University, Neyshabour Branch The Effect of Aerobic Exercise on Patients with Heart Failure The Effect of Eight Weeks of Continuous and Periodic Aerobic Exercise on some Adhesive Molecules and Inflammatory Indices in Men with Heart Failure 2018-08-05 anticipated 42 Complete https://irct.ir/trial/32828 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: After screening, these subjects were randomly assigned to control group (n = 14), continuing aerobic exercise group (n = 14) and periodic aerobic exercise group (n = 14). The randomization method will be performed using the random number table. Considering the numbers from 0 to 14 for the control group, the numbers from 14 to 28 for the continuing aerobic exercise group, numbers 28 to 42 for the periodic aerobic exercise group. The researcher chooses one of the numbers and moves in the preset direction and assigns the number for the relevant group. N/A Heart failure. Intervention 1: Intervention group1: This group carries out continuous aerobic exercise. Continuous aerobic exercise program (with intensity of 45-70% of maximum heart rate) for 8 weeks (3 sessions per week and 30-50 minutes each session)will be performed, which is designed using treadmill. At the beginning of each session, 10 min of stretching exercise were performed to warm up, and during the training the subjects were monitored.The intensity of exercise is controlled and recorded using heart rate and ECG then at the end of the training, the subjects will cool down using stretching exercises. Intervention 2: Intervention group 2: In this group, the Periodic aerobic exercise program (with three sessions per week, and a intensity of 45-80% of the maximum heart rate) will be design using treadmill and wheelchair. Subjects have resting period between 5-10 minutes according to individual circumstances. At the beginning of each session, 10 min of stretching exercise were performed to warm up, and during the training the subjects were monitored.The intensity of exercise is controlled and recorded using heart rate and ECG then at the end of the training, the subjects will cool down using stretching exercises. Intervention 3: Control group: The control group will not have any physical activity other than doing routine work. Yes - There is a plan to make this available What will be shared: Data related to the indices (IL-6, TNF-α, hs-CRP, ICAM-1, VCAM-1, E-selectin, P-selectin) will be shared. When: From 2019 To whom: Academic researchers Conditions: Use with reference Where to obtain: ladan.abrishami@gmail.com How to obtain: Maximum one week Comments:
public Ladan Hosseni Abrishami
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Mashhad Iran (Islamic Republic of) 9177966761 +98 51 3881 6133 ladan.abrishami@gmail.com Islamic Azad University, Neyshabour Branch scientific Ladan Hosseni Abrishami
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Mashhad Iran (Islamic Republic of) 9177966761 +98 51 3881 6133 ladan.abrishami@gmail.com Islamic Azad University, Neyshabour Branch Iran (Islamic Republic of) Men aged 50-60 years old with heart failure grade 1-3 according to New York Heart Association (NYHA) criteria; have a heart power of less than 45% and in terms of physical fitness; have potential for exercises. 50 years 60 years Male Having a history of heart disease less than 5 years old, having regular exercise regularly during the past six months, and performing other exercises along with the exercises during the study period, patient dissatisfaction with continued participation in the study; exacerbation of symptoms of heart failure; cardiac arrhythmias; cardiac ischemia; high blood pressure crisis; neurological problems; orthopedic problems. I50 Heart failure Rehabilitation Rehabilitation N/A Intervention group1: This group carries out continuous aerobic exercise. Continuous aerobic exercise program (with intensity of 45-70% of maximum heart rate) for 8 weeks (3 sessions per week and 30-50 minutes each session)will be performed, which is designed using treadmill. At the beginning of each session, 10 min of stretching exercise were performed to warm up, and during the training the subjects were monitored.The intensity of exercise is controlled and recorded using heart rate and ECG then at the end of the training, the subjects will cool down using stretching exercises. Intervention group 2: In this group, the Periodic aerobic exercise program (with three sessions per week, and a intensity of 45-80% of the maximum heart rate) will be design using treadmill and wheelchair. Subjects have resting period between 5-10 minutes according to individual circumstances. At the beginning of each session, 10 min of stretching exercise were performed to warm up, and during the training the subjects were monitored.The intensity of exercise is controlled and recorded using heart rate and ECG then at the end of the training, the subjects will cool down using stretching exercises. Control group: The control group will not have any physical activity other than doing routine work. Serum IL-6 level. Timepoint: At the beginning of the study and 8 weeks after the intervention. Method of measurement: Serum concentrations of IL-6 (pg/ml), Using high-sensitivity ELISA kits. Serum TNF-α level. Timepoint: At the beginning of the study and 8 weeks after the intervention. Method of measurement: Serum concentrations of TNF-α (pg/ml), Using high-sensitivity ELISA kits. Serum hs-CRP level. Timepoint: At the beginning of the study and 8 weeks after the intervention. Method of measurement: Serum concentrations of hs-CRP (ml/l), Using high-sensitivity ELISA kits. Serum ICAM-1 level. Timepoint: At the beginning of the study and 8 weeks after the intervention. Method of measurement: Serum concentrations of ICAM -1 (ng/ml), Using high-sensitivity ELISA kits. Serum VCAM-1 level. Timepoint: At the beginning of the study and 8 weeks after the intervention. Method of measurement: Serum concentrations of VCAM -1 (ng/ml), Using high-sensitivity ELISA kits. Serum E-selectin level. Timepoint: At the beginning of the study and 8 weeks after the intervention. Method of measurement: Serum concentrations of E-selectin (ng/ml), Using high-sensitivity ELISA kits. Serum P-selectin level. Timepoint: At the beginning of the study and 8 weeks after the intervention. Method of measurement: Serum concentrations of P-selectin (ng/ml), Using high-sensitivity ELISA kits. Islamic Azad University, Neyshabour Branch Approved 2018-06-12 Sport Sciences Research Institute of Iran No. 3, 5th Alley, Mir Emad Ave. Tehran Tehran Iran (Islamic Republic of)