IRCT201207153226N4 IRCT 2013-12-20 The International Branch of Shahid Beheshti university of medical sciences The comparison of the effect of garsin and metronidazole on bacterial vaginosis The comparison of the effects of garsin tablet ( made of garlic ) and metronidazole tablet on treatment of bacterial vaginosis 2013-12-16 anticipated 140 Complete https://irct.ir/trial/3291 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A Bacterial vaginosis infection. Intervention 1: One group Metronidazole 250 mg tablet, twice daily 500 mg (every 12 hours) with food for 7 days. Intervention 2: the other group Garsin 500 mg tablet, twice daily 1000 mg (every 12 hours) with meal for 7 days.

public Farnaz Mohammadzadeh

St. Valiasr, intersection of Valiasr -Niyayesh, School of nursing and midwifery, shaheed Beheshti University of Medical Sciences

Tehran Iran (Islamic Republic of) 1985717443 +98 21 8865 5366 farnaz.mohammadzade@gmail.com; sbnmf@sbmu.ac.ir The International Branch of Shahid Beheshti university of medical sciences Iran (Islamic Republic of) Inclusion criteria: married women; aged 18-44 years old, with single partner whose infection with bacterial vaginosis is diagnosed through clinical Amsel criteria and labratory Nugent criteria ( Patients identified with cervicitis tricamona or candidiadis infections are excluded from the study); they should not use IUD. Also they should not use antibiotics, vaginal drug or immunosuppressive drugs in recent fourteen days. During clinical examination they should not have any breakthrough bleeding or menstrual period. They should not be pregnant, lactating or menopause. They should not have mental retardation or known physical disease; suffering from thyroid disease; coagulation disorders; diabetes and autoimmune diseases. Exclusion criteria: not tolerate any form of drug or discontinuation for at least 48 hours, become pregnant during treatment, forcing the use of antibiotics during treatment. 18 years 44 years Female N77 Vulvovaginal ulceration and inflammation in diseases classified elsewhere Treatment - Drugs Treatment - Drugs One group Metronidazole 250 mg tablet, twice daily 500 mg (every 12 hours) with food for 7 days the other group Garsin 500 mg tablet, twice daily 1000 mg (every 12 hours) with meal for 7 days. Amsel criteria. Timepoint: Before the intervention, 7-10 days after begining of treatment. Method of measurement: Amsel have 4 criteria: key cells in the wet mount vaginal sample Vaginal dyscharge thin and white uniform - gray, white or yellowish, Vaginal pH equal to or greater than 4/5, positive whiff test. If at least 3 of the 4 cases mentioned above is positive, bacterial vaginosis is brought on . Nugent criteria. Timepoint: Before the intervention, 7-10 days after beginning treatment. Method of measurement: These criteria are based on the observation lactobacil and other morphotype (Gardnerella vaginalis and Mobiluncus forms) are rated from zero to 10 points, a total score of 7-10 means abnormal vaginal flora (bacterial vaginosis), grades 4-6 (Intermediate) in this study means abnormal vaginal flora. normal flora score is 0-3. Bacterial vaginosis infection. Timepoint: Before the intervention, 7-10 days after beginning treatment. Method of measurement: Clinical complaint questionnaires are completed by samples (itching, burning, abnormal discharge, smelly discharge). The International Branch of Shahid Beheshti university of medical sciences Approved 2013-10-07 The International Branch of Shahid Beheshti university of medical sciences & health sciences No.19, Adjacent to Hemmat bridge, shaheed Abbaspour ave, Valiasr street,Tehran.Iran Tehran Iran (Islamic Republic of)