IRCT20150630022991N13 IRCT 2018-10-12 Babol University of Medical Sciences Escitalopram, fluoxetine and vitagnus in premenstrual dysphoric disorder Comparison the effectiveness and side effects of three drugs- escitalopram, fluoxetine and vitagnus- in premenstrual dysphoric disorder 2018-08-06 anticipated 75 Complete https://irct.ir/trial/32920 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: In order to random allocation of patients into the three groups of citalopram, fluoxetine and vitagnus, block randomization will be conducted. The free website of www.randomization.com is used to provide the sequence of allocation. The resulting sequence is written in separate sheets and placed in closed envelopes. These will be delivered to the chief researcher to conduct the study. 2-3 Premenstrual dysphoric disorder. Intervention 1: Intervention group 1: Escitalopram manufactured in Abidi´s Pharmaceutical Company 10 milligram per day for three months. Intervention 2: Intervention group 2: Vitagnus tablets manufactured in Poursina Pharmaceutical Company 20 milligram per day for three months. Intervention 3: Control group: Fluoxetine manufactured in Abidi´s Pharmaceutical Company 20 milligram per day for three months. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no more information.