]>

IRCT20171106037280N3 IRCT 2019-01-28 Sanandaj University of Medical Sciences The effects of etomidate and ketamine on outcome of adult patients with multiple trauma requiring tracheal intubation Comparison of the effects of etomidate versus ketamine on outcome of adult patients with multiple trauma requiring rapid sequence intubation 2019-01-10 anticipated 80 Complete https://irct.ir/trial/32996 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: simple randomization with allocating random numbers to patients and selecting the drug based on that number, Blinding description: Patients and medications are marked with numbers which are unknown for patients and investigators, at the end of the study it is revealed that which number is representative of which medication for each patient. 3 intubation in trauma patient. Intervention 1: Intervention group1:ketamine: ketamine 3 mg/kg IV infusion, administered once at the beginning of the intervention for induction during rapid sequence intubation. Intervention 2: Intervention group2:etomidate: etomidate 0.3 mg/kg IV infusion, administered once at the beginning of the intervention for induction during rapid sequence intubation. Yes - There is a plan to make this available What will be shared: The collected data about outcome will be disclosed When: The data will be published 1 year after the results. To whom: Students and physicians and lecturers Conditions: Data can be used under copyright rules. Where to obtain: Data will be in access by sending an e-mail to H-sotude@razi.tums.ac.ir. How to obtain: The data would be reachable for whom with a qualified letter from research department of their university or institute. Comments:

public Hamed Sotoude

Sanandaj, Pasdaran st., Kowsar hospital, emergency department

Sanandaj Iran (Islamic Republic of) 6618634683 +98 87 3366 2027 H-sotude@razi.tums.ac.ir Sanandaj University of Medical Sciences scientific Hamed Sotoude

Sanandaj, Pasdaran st., Kowsar hospital, emergency department

Sanandaj Iran (Islamic Republic of) 6618634683 +98 87 3366 2027 H-sotude@razi.tums.ac.ir Sanandaj University of Medical Sciences Iran (Islamic Republic of) All adult multiple trauma patients referring to Sanandaj Kowsar Hospital emergency department requiring rapid sequence tracheal intubation 18 years no limit Both allergy to drugs elevated intracerebral or intraocular pressure hypertention (Blood Pressure>= 160/110 mm Hg) severe endocrine disorders active lung disease tracheal stenosis obstructive sleep apnea airway obstruction laryngospasm pregnancy or lactation Treatment - Drugs Treatment - Drugs Intervention group1:ketamine: ketamine 3 mg/kg IV infusion, administered once at the beginning of the intervention for induction during rapid sequence intubation. Intervention group2:etomidate: etomidate 0.3 mg/kg IV infusion, administered once at the beginning of the intervention for induction during rapid sequence intubation. Death at emergency department or during admission at hospital. Timepoint: During emergency department and hospital admission. Method of measurement: Death declaration at his/her documents. Duration of survival days during hospital admission. Timepoint: During emergency or hospital admission (from admission and intubation until death). Method of measurement: Number of survival days. ICU-free days. Timepoint: During hospital admission from intubation to 28 days after admission (ICU-discharge point until 28 days after admission). Method of measurement: Number of ICU-free days. Ventilator-free days. Timepoint: During hospital admission from intubation to 28 days after admission (the time of weaning from mechanical ventilation until 28 days after admission). Method of measurement: Number of ventilator-free days. Vasopressor free days. Timepoint: During hospital admission from intubation to 28 days after admission (the time of stopping vasopressor infusion until 28 days after admission). Method of measurement: Number of vasopressor-free days. Number of transfused packed-RBCs. Timepoint: During the first 48 hours from admission. Method of measurement: Number of transfused packed-RBCs documented on patient file. Sepsis incidence. Timepoint: During the first 28 days from admission. Method of measurement: Having 2 or more criteria form SIRS associated with an infection focus during the first 28 days from admission. Sanandaj University of Medical Sciences Approved 2018-03-14 Ethics committee of Kurdistan University of Medical Sciences Pasdaran St., Kurdistan University of Medical Sciences, Research Department Sanandaj Kurdistan Iran (Islamic Republic of)