IRCT20090801002266N8 IRCT 2018-10-31 Esfahan University of Medical Sciences َAntidepressant effect of ketamine Comparison of anti-depressant effect of oral ketamine, intramuscular ketamine and electroconvulsive therapy in the patients with major depressive disorder 2018-10-12 anticipated 45 Complete https://irct.ir/trial/33082 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: In this study the patients divides into three 15 individual groups which receive electro convulsive therapy, 1mg/kg oral ketamine and 0.5 mg/kg intramuscular ketamine through 3 weeks in 6-9 sessions. the 17 items Hamilton depression scale(17-HDS) and beck scale for suicidal ideation (BSSI) will be assessed and compared between groups in specific intervals and one month after last intervention. also the satisfaction of each group will be assessed with a questionnaire and compared between groups, Randomization description: The selected 45 cases in this study, will be divided in three intervention groups as block randomization, with sealed envelops numbered 1 to 45 in which there is an intervention method, that is randomly selected with computer software. 2-3 Major depressive disorder. Intervention 1: First intervention group: intra muscular ketamine, NMDA antagonist, 0.5mg/kg dosage, 500 mg vial, rotex medica factory in Germany, 6-9 injection through 3weeks. Intervention 2: Second intervention group: intra muscular ketamine, NMDA antagonist, 1mg/kg dosage, 500 mg vial, rotex medica factory in Germany, 6-9 prescription through 3 weeks in which the injectable ketamine will be added to juice and will be taken orally. Intervention 3: Third intervention group: the bilateral electroconvulsive therapy group that begin with 25mC after short anesthesia in 6-9 sessions through three weeks. No - There is not a plan to make this available Justification or reason for not sharing IPD is there is no further information