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IRCT20180806040721N2 IRCT 2018-10-20 Shiraz University of Medical Sciences The effects of eight weeks aerobic, resistance, and combined exercises on plasma Irisin levels, insulin resistance and lipid profiles among obese women with metabolic syndrome The effects of eight weeks aerobic, resistance, and combined exercises on plasma Irisin levels, insulin resistance and lipid profiles among obese women with metabolic syndrome 2016-12-01 anticipated 60 Complete https://irct.ir/trial/33111 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 3 Condition 1: Metabolic syndrome. Condition 2: Diabets. Intervention 1: Intervention group first: Aerobic training group En. Participants of this group performed their activities using treadmill or bicycle three times per week (on non consecutive days). Time of exercise was increased from 20 minutes per session (at 60% of maximum heart rate) to 60 minutes (at 75% of maximum heart rate) per session. Heart rate was regularly determined by the monitor’s treadmill or cycle ergometers. Required heart rate was calculated by the Karvonen formula. Intervention 2: Intervention group second: Resistance training group En. Resistance training group This program was performed on different weight machines. Correct training techniques were instructed and supervised by professional trainers. The protocol was started on 2 days of the week during the first month and was increased to 3 non-consecutive days per week. Training was started during weeks 1 and 2 with intensity 60% onerepetition maximum (1RM) and was progressed to intensity 75-80% 1RM. The number of sets was 1-2 during the first month. This program included 10 different exercises for upper and lower body. Participants performed 3 sets of 8-10 repetitions (with a 90- 120 s rest between sets) of the following exercises: bench press, seated row, shoulder press, chest press, lateral pulldown, abdominal crunches, leg press, leg extension, triceps pushdown and seated bicep curls. Intervention 3: Intervention group third: Combined training group (aerobic-resistance) En. Combined training group (aerobic-resistance) The subjects of this group did the aerobic exercise plus resistance training programs 3 times a week. After a warm-up stage, they worked for 20-30 minutes on a treadmill or bicycle plus 2 sets of each of 8 exercises with 8-10 repetitions on weight machines. Intervention 4: control group: control group .En control group: control group A group that did not have any training intervention. No - There is not a plan to make this available Justification or reason for not sharing IPD is Disagreement with contractors to share their profile and data
public Dianatinasab Mostafa
Motahhari Street
Shiraz Iran (Islamic Republic of) 591-535121 +98 71 5383 4701 dianatinasab@sums.ac.ir Shiraz University of Medical Sciences scientific Dianatinasab Mostafa
Motahhari Street
Shiraz Iran (Islamic Republic of) 591-535121 +98 71 5383 4701 dianatinasab@sums.ac.ir Shiraz University of Medical Sciences Iran (Islamic Republic of) Having at least 3 components of metabolic syndrome Women 45-60 years old No history of any specific disease (cancer, diabetes, cardiovascular problems, Skeletal-muscular problems) 45 years 60 years Female diagnosed with history of any specific disease (cancer, diabetes, cardiovascular problems, Skeletal-muscular problems) E88.81 E08 Metabolic syndrome Diabetes mellitus due to underlying condition Treatment - Devices Treatment - Devices Treatment - Devices Other Intervention group first: Aerobic training group En. Participants of this group performed their activities using treadmill or bicycle three times per week (on non consecutive days). Time of exercise was increased from 20 minutes per session (at 60% of maximum heart rate) to 60 minutes (at 75% of maximum heart rate) per session. Heart rate was regularly determined by the monitor’s treadmill or cycle ergometers. Required heart rate was calculated by the Karvonen formula Intervention group second: Resistance training group En. Resistance training group This program was performed on different weight machines. Correct training techniques were instructed and supervised by professional trainers. The protocol was started on 2 days of the week during the first month and was increased to 3 non-consecutive days per week. Training was started during weeks 1 and 2 with intensity 60% onerepetition maximum (1RM) and was progressed to intensity 75-80% 1RM. The number of sets was 1-2 during the first month. This program included 10 different exercises for upper and lower body. Participants performed 3 sets of 8-10 repetitions (with a 90- 120 s rest between sets) of the following exercises: bench press, seated row, shoulder press, chest press, lateral pulldown, abdominal crunches, leg press, leg extension, triceps pushdown and seated bicep curls Intervention group third: Combined training group (aerobic-resistance) En. Combined training group (aerobic-resistance) The subjects of this group did the aerobic exercise plus resistance training programs 3 times a week. After a warm-up stage, they worked for 20-30 minutes on a treadmill or bicycle plus 2 sets of each of 8 exercises with 8-10 repetitions on weight machines control group: control group .En control group: control group A group that did not have any training intervention Irisin. Timepoint: measurement at the beginning of the study (before the intervention) and 2 months after the intervention. Method of measurement: Measurement Plasma Irisin Level Using Elis Kit Made in Germany. Glocose. Timepoint: At the beginning of the study (before the intervention) and two months after the intervention began. Method of measurement: fasting blood glucose (glucose oxidase) measured. Insulin. Timepoint: At the beginning of the study (before the intervention) and two months after the intervention began. Method of measurement: The level of insulin was measured by ELISA. Triglyceride. Timepoint: At the beginning of the study (before the intervention) and two months after the intervention began. Method of measurement: triglyceride (PAP-GPO / lipase) measured. Shiraz University of Medical Sciences Approved 2018-07-02 Shiraz University of Medical Sciences Ethics Committee Eram Street Shiraz Fars Iran (Islamic Republic of)